지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 290 - 296 (7page)
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초록· 키워드
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Objective The risks of cigarette smoking concerning higher systemic disease mortality are lessened by smoking cessation.
Methods Microarray analysis compared the expression profiles of smokers who were successful and not successful at smoking cessation, with the goal of identifying genes that might serve as potential biomarkers or that might be valuable in elucidating distinct biological mechanisms. The mRNAs were isolated and compared from peripheral leukocytes of six smokers who were successful in cessation and six smokers who failed in smoking cessation.
Results Two hundred ninety nine genes displayed significantly different expression; 196 genes were up-regulated and 103 genes were down-regulated in the success group compared to the failure group. Twenty four of these genes were identified with biological processes including immunity, cytoskeleton and cell growth/cycle. Real-time PCR confirmed the differential gene expression. The mRNA levels of HEPACAM family member 2 (HEPACAM2) and tropomodulin 1 (TMOD1) were significantly more expressed in the success group, while the mRNA ubiquitin specific peptides 18 (USP18) were significantly less expressed in the success group compared to the failure group.
Conclusion The results suggest that smoking cessation can modulate cell adhesion and immune response by regulating expression levels of genes, especially HEPACAM2, TMOD1 and USP18, which have an important relationship with smoking cessation.
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참고문헌 (42)
참고문헌 신청
Ambrose JA / 2004 / The pathophysiology of cigarette smoking and cardiovascular disease: an update / J Am Col Cardiol 43:1731~1737
Azim AC / 1995 / Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily / J Biol Chem 270:17407~17413
Miraglia del Giudice E / 1998 / High frequency of de novo mutations in ankyrin gene (ANK1) in children with hereditary spherocytosis / J Pediatr 132:117~120
Parra M / 2004 / Differential domain evolution and complex RNA processing in a family of paralogous EPB41 (protein 4.1) genes facilitate expression of diverse tissue-specific isoforms / Genomics 84:637~646
Kitahara T / 1994 / Up-regulation of ERK (MAP kinase) and MEK (MAP kinase kinase) transcription after rat facial nerve transection / Neurosci Res 20:275~280
Azim AC / 1995 / Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily / J Biol Chem 270:17407~17413
Miraglia del Giudice E / 1998 / High frequency of de novo mutations in ankyrin gene (ANK1) in children with hereditary spherocytosis / J Pediatr 132:117~120
Parra M / 2004 / Differential domain evolution and complex RNA processing in a family of paralogous EPB41 (protein 4.1) genes facilitate expression of diverse tissue-specific isoforms / Genomics 84:637~646
Kitahara T / 1994 / Up-regulation of ERK (MAP kinase) and MEK (MAP kinase kinase) transcription after rat facial nerve transection / Neurosci Res 20:275~280
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