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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 44 - 49 (6page)
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초록· 키워드
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Objective: We examined the association between the tryptophan hydroxylase 1 (TPH1) gene and eating disorders focusing on obsessionality.
Methods: The sample included 62 women with a lifetime diagnosis of anorexia nervosa (AN) as well as 50 women with a lifetime diagnosis of bulimia nervosa (BN) recruited from specialist clinics for eating disorders and 131 healthy women in Korea. Blood samples were collected from all participants for the TPH1 genotyping. The patients were ad ministered the Korean version of the Eating Disorders Examination and obsessionality was conceptualized
using measures of persistence, harm avoidance, and obsessive-compulsive symptoms.
Results: In the case-control comparisons, the frequency of the A/A genotype was increased in the patients with BN, but this difference was not significant after correcting for multiple testing. We found no effect of the TPH A218C polymorphism on obsessionality in the patients with AN or BN.
Conclusion: Although the present findings should be regarded as preliminary because of the small size of our sample, they suggest that the TPH1 gene may contribute to the genetic susceptibility to BN and be associated with the other unexplored traits of bulimic case status.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders / American Psychiatric Association
Bulik CM / 2005 / Selection of eating-disorder phenotypes for linkage analysis / Am J Med Genet B Neuropsychiatr Genet 139B : 81 ~ 87
Cho DK / 1985 / The standardization of Maudsley Obsessive Compulsive Inventory / Seoul National University Student Review 20 : 81 ~ 90
Clarke HF / 2004 / Cognitive inflexibility after prefrontal serotonin depletion / Science 304 : 878 ~ 880
Cloninger CR / 1994 / Temperament and personality / Curr Opin Neurobiol 4 : 266 ~ 273
Bulik CM / 2005 / Selection of eating-disorder phenotypes for linkage analysis / Am J Med Genet B Neuropsychiatr Genet 139B : 81 ~ 87
Cho DK / 1985 / The standardization of Maudsley Obsessive Compulsive Inventory / Seoul National University Student Review 20 : 81 ~ 90
Clarke HF / 2004 / Cognitive inflexibility after prefrontal serotonin depletion / Science 304 : 878 ~ 880
Cloninger CR / 1994 / Temperament and personality / Curr Opin Neurobiol 4 : 266 ~ 273
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