지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 260 - 262 (3page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaAltered serum S100B protein levels have been shown in several psychiatric disorders. Our aim was to investigate whether plasma S100B is different in patients with panic disorder (PD) when compared with controls. Our second aim was to investigate whether treatment with SSRIs have an effect on S100B levels in patients with PD.
MethodsaaThe sample included 32 patients diagnosed with PD (21 women, 11 men) per DSM-IV criteria and 21 healthy controls (11 women, 10 men). S100B levels were measured with BioVendor Human S100B ELISA (Enzyme Linked Immunosorbent Assay) kit.
Resultsaa14 patients were not on drug treatment (43.8%) while 18 patients were taking various SSRIs. Median S100B value was 151.7 pg/mL (minimum-maximum: 120.4–164.7 pg/mL) in the control group, 147.4 pg/mL (minimum-maximum: 138.8–154.1 pg/mL) in the drug free group and 153.0 pg/mL (minimum-maximum: 137.9–164.7 pg/mL) in the treatment group. Kruskal-Wallis analysis showed a significant diffrerence among the three groups (z=9.9, df=2, p=0.007). Follow up Mann-Whitney-U tests indicated that while the control and the patients with treatment were not significantly different (z=-0.05, p=0.96), there were significant differences between the control group and untreated patients (z=-2.6, p=0.009) and treated and untreated patients (z=-3.0, p=0.003).
ConclusionaaOur results suggested that, serum S100B protein level might be decreased in untreated PD patients and that patients who were treated with SSRIs had similar S100B level to healthy controls.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Adami C / 2001 / S100B expression in and effects on microglia / Glia 33 : 131 ~ 142
Akhisaroglu M / 2003 / Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus / Neuroreport 14 : 1471 ~ 1473
Bock N / 2013 / Chronic fluoxetine treatment changes S100B expression during postnatal rat brain development / J Child Adolesc Psychopharmacol 23 : 481 ~ 489
Deakin JF / 1991 / 5-HT and mechanisms of defence / J Psychopharmacol 5 : 305 ~ 315
Dietrich DE / 2004 / Target evaluation processing and serum levels of nerve tissue protein S100B in patients with remitted major depression / Neurosci Lett 354 : 69 ~ 73
Akhisaroglu M / 2003 / Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus / Neuroreport 14 : 1471 ~ 1473
Bock N / 2013 / Chronic fluoxetine treatment changes S100B expression during postnatal rat brain development / J Child Adolesc Psychopharmacol 23 : 481 ~ 489
Deakin JF / 1991 / 5-HT and mechanisms of defence / J Psychopharmacol 5 : 305 ~ 315
Dietrich DE / 2004 / Target evaluation processing and serum levels of nerve tissue protein S100B in patients with remitted major depression / Neurosci Lett 354 : 69 ~ 73
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