지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Objectives The author investigated the relationship between the environmental tobacco smoke exposure during mid-pregnancy and early childhood and neurobehavioral outcomes of preschool children and if there is any effect of the genetic polymorphism of glutathione S-transferase (GST) M1 and T1 on this relationship.
Methods The participants were the pregnant women (week 24-28) who visited the obstetrics and gynecology department (between 2001 and 2004). They had been evaluated for their sociodemographic data including direct and environmental tobacco smoke exposure history and the urine specimen had been sampled for the measurement of cotinine. The offsprings’ urine specimen and blood sampling had been done and the socioeconomic data including the environmental tobacco smoke exposure history was evaluated at age 3. The cotinine level of urine specimen was measured and GST polymorphism was analyzed. The offsprings completed Korean-Childhood Behavioral Check List (K-CBCL) at age 4-5.
Results The environmental tobacco smoke exposure during mid-pregnancy based on urine cotinine level has a significant association with increased total score and externalizing problem score of K-CBCL (p<0.05). The environmental tobacco smoke exposure based on urine cotinine level at age 3 is associated increased total score, externalizing problem score and internalizing problem score of K-CBCL with no statistical significance. The environmental tobacco smoke exposure after controlling for tobacco smoke exposure during pregnancy, however, is significantly associated with the increased externalizing problem scores (p=0.04). The environmental tobacco smoke exposure is associated with increased total score, externalizing problem score and internalizing problem score of K-CBCL with GSTM1 null type or GSTT1 null type at age 3 although there was no statistical significance.
Conclusion The environmental tobacco smoking exposure during pregnancy and at early childhood is associated with childhood behavioral problems. The clinical implication of this study is that it is important to avoid the environmental tobacco smoke exposure during pregnancy and early childhood and to monitor the possible emergence of behavioral problems of children.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
/ 2008 / Maternal exposure to environmental tobacco smoke, GSTM1/T1 polymorphisms and oxidative stress / REPRODUCTIVE TOXICOLOGY 26 : 197 ~ 202
Achenbach TM / 1991 / Manual for the Child Behavior Check List/4-18 and 1991 Profile / Burlington: University of Vermont
Anderko L / 2010 / Contribution of tobacco smoke exposure to learning disabilities / J Obstet Gynecol Neonatal Nurs 39 : 111 ~ 117
Batstra L / 2003 / Effect of antenatal exposure to maternal smoking on behavioural problems and academic achievement in childhood: prospective evidence from a Dutch birth coh
Boutwell BB / 2010 / Maternal cigarette smoking during pregnancy and offspring externalizing behavioral problems: a propensity score matching analysis / Int J Environ Res Pu
Achenbach TM / 1991 / Manual for the Child Behavior Check List/4-18 and 1991 Profile / Burlington: University of Vermont
Anderko L / 2010 / Contribution of tobacco smoke exposure to learning disabilities / J Obstet Gynecol Neonatal Nurs 39 : 111 ~ 117
Batstra L / 2003 / Effect of antenatal exposure to maternal smoking on behavioural problems and academic achievement in childhood: prospective evidence from a Dutch birth coh
Boutwell BB / 2010 / Maternal cigarette smoking during pregnancy and offspring externalizing behavioral problems: a propensity score matching analysis / Int J Environ Res Pu
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