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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 593 - 601 (9page)
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ObjectiveaaUric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD. MethodsaaA total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in case of patients. Tract-based spatial statistics were used for all imaging analyses. ResultsaaLower fractional anisotropy (FA) and higher radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM. ConclusionaaThe present study suggests a significant association between altered WM connectivity and serum uric acid levels in patients with MDD, possibly through demyelination.
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참고문헌 (89)
참고문헌 신청
Nutt DJ / 2008 / Relationship of neurotransmitters to the symptoms of major depressive disorder / J Clin Psychiatry 69(Suppl E1):4~7
Coppen A / 1967 / The biochemistry of affective disorders / Br J Psychiatry 113:1237~1264
Schildkraut JJ / 1965 / The catecholamine hypothesis of affective disorders: a review of supporting evidence / Am J Psychiatry 122:509~522
Rush AJ / 2006 / Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report / Am J Psychiatry 163:1905~1917
Holsboer F / 2000 / The corticosteroid receptor hypothesis of depression / Neuropsychopharmacology 23:477~501
Coppen A / 1967 / The biochemistry of affective disorders / Br J Psychiatry 113:1237~1264
Schildkraut JJ / 1965 / The catecholamine hypothesis of affective disorders: a review of supporting evidence / Am J Psychiatry 122:509~522
Rush AJ / 2006 / Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report / Am J Psychiatry 163:1905~1917
Holsboer F / 2000 / The corticosteroid receptor hypothesis of depression / Neuropsychopharmacology 23:477~501
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