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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 8 - 17 (10page)
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Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a valuable opportunity to study neurodevelopmental and neurodegenerative psychiatric diseases by offering an unlimited source for patient-specific neuronal and glial cells. The present review focuses on the recent advancements in modeling psychiatric disorders such as Phelan-McDermid syndrome, Timothy syndrome, Rett syndrome, schizophrenia, bipolar disorder, and dementia. The treatment effects identified in studies on iPSCs using known therapeutic compounds are also summarized in this review. Here we discuss validation of cellular models and explore iPSCs as a novel drug screening tool. Although there are several limitations associated with the current methods used to study mental disorders, using iPSCs as a model system provides the advantage of rewinding and reviewing the development and degeneration of human neural cells.
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참고문헌 (69)
참고문헌 신청
Nestler EJ / 2010 / Animal models of neuropsychiatric disorders / Nat Neurosci 13:1161~1169
Takahashi K / 2006 / Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors / Cell 126:663~676
Gonzalez F / 2011 / Methods for making induced pluripotent stem cells : reprogramming a la carte / Nat Rev Genet 12:231~242
Takahashi K / 2007 / Induction of pluripotent stem cells from adult human fibroblasts by defined factors / Cell 131:861~872
Swistowski A / 2010 / Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions / Stem Cells 28:1893~1904
Takahashi K / 2006 / Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors / Cell 126:663~676
Gonzalez F / 2011 / Methods for making induced pluripotent stem cells : reprogramming a la carte / Nat Rev Genet 12:231~242
Takahashi K / 2007 / Induction of pluripotent stem cells from adult human fibroblasts by defined factors / Cell 131:861~872
Swistowski A / 2010 / Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions / Stem Cells 28:1893~1904
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