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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 869 - 875 (7page)
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초록· 키워드
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ObjectiveaaLittle is known about the natural course of pre-mild cognitive impairment (pre-MCI) and predictors to MCI. We followedup individuals with pre-MCI and cognitively normal (CN) elders to identify neuropsychological predictors for rapid conversion to MCI. MethodsaaSeventy-seven individuals with pre-MCI and 180 CN elders were recruited from the pool of individuals registered at the National Research Center for Dementia in Gwangju, Korea. We followed-up with them after a mean of 14±2.29 months. All participants underwent comprehensive clinical and neuropsychological assessment. Logistic regression analysis examined the ability of neuropsychological tests to predict conversions to MCI. ResultsaaOf 257 participants, 142 (55.3%) were eligible for the follow-up study (102 CN, 40 pre-MCI). Logistic regression revealed that spatial delayed recall significantly predicted the conversion from pre-MCI to MCI. In CN, copy for a complex figure significantly predicted the conversion to pre-MCI or MCI. ConclusionaaOur findings indicated that spatial delayed recall was associated with rapid conversion from pre-MCI to MCI. Spatial organization and planning, measured by complex figure reproduction, were associated with rapid conversion from CN to pre-MCI or MCI. Our study suggests that inclusion of visuospatial reproduction and memory using a complex figure further facilitates early detection of MCI.
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등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Sperling RA / 2011 / Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease / Alzheimers Dement 7:280~292
Dubois B / 2016 / Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria / Alzheimers Dement 12:292~323
Storandt M / 2006 / Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI / Neurology 67:467~473
Clark DG / 2016 / Novel verbal fluency scores and structural brain imaging for prediction of cognitive outcome in mild cognitive impairment / Alzheimers Dement (Amst) 2:113~122
Ding D / 2016 / Progression and predictors of mild cognitive impairment in Chinese elderly: a prospective follow-up in the Shanghai Aging Study / Alzheimers Dement (Amst) 4:28~36
Dubois B / 2016 / Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria / Alzheimers Dement 12:292~323
Storandt M / 2006 / Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI / Neurology 67:467~473
Clark DG / 2016 / Novel verbal fluency scores and structural brain imaging for prediction of cognitive outcome in mild cognitive impairment / Alzheimers Dement (Amst) 2:113~122
Ding D / 2016 / Progression and predictors of mild cognitive impairment in Chinese elderly: a prospective follow-up in the Shanghai Aging Study / Alzheimers Dement (Amst) 4:28~36
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