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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 52 - 57 (6page)
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초록· 키워드
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Purpose: To obtain basic data for development of a
glioblastoma-specific immunotoxin, the expression of
variable cell surface receptors on a human glioblastoma
xenograft model was evaluated, using NOD/SCID mice.
Materials and Methods: We developed a xenograft
model in NOD/SCID mice implanted with a human
glioblastoma cell line (U-87MG). Immunohistochemical
studies were performed on implanted tumor nodules
(n=8) using antibodies against CD71, EGFR, IGF-IRα,
CXCR4 and IL-4Rα.
Results: Expression of IL-4Rα, in implanted tumor
nodules, was the highest of the cell surface receptors
evaluated in this study. However, the endothelial cells in,
and around, the tumor nodules also revealed immunopositivity
against IL-4Rα. The immunoreactivity of IL-4R
α, and other surface receptors such as CD71, IGF-IRα
and EGFR, was prominent in tumor nodules associated
with tumor necrosis.
Conclusion: IL-4Rα would be a possible target for the
development of glioblastoma-specific immunotoxin, although
there are limitations due to its endothelial expression.
(Cancer Res Treat. 2002;34:52-57)
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