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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 304 - 313 (10page)
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초록· 키워드
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Purpose: This study utilized both mRNA differential
display and the Gene Ontology (GO) analysis to characterize
the multiple interactions of a number of genes
with gene expression profiles involved in the HPV-16-
induced cervical carcinogenesis.
Materials and Methods: mRNA differential displays,
with HPV-16 positive cervical cancer cell line (SiHa), and
normal human keratinocyte cell line (HaCaT) as a control,
were used. Each human gene has several biological
functions in the Gene Ontology; therefore, several functions
of each gene were chosen to establish a powerful
cervical carcinogenesis pathway. The specific functions
assigned to these genes were then correlated with the
gene expression patterns.
Results: The results showed that 157 genes were upor
down-regulated at least 2-fold and organized into
reciprocally dependent sub-function sets, depending on
their cervical cancer pathway, suggesting the potentially
significant genes of unknown function affected by the
HPV-16-derived pathway. The GO analysis suggested that
the cervical cancer cells underwent repression of the
cancer-specific cell adhesive properties. Also, genes
belonging to DNA metabolism, such as DNA repair and
replication, were strongly down-regulated, whereas significant
increases were shown in the protein degradation
and synthesis.
Conclusion: The GO analysis can overcome the complexity
of the gene expression profile of the HPV-16-
associated pathway, identify several cancer-specific cellular
processes and genes of unknown function. It could
also become a major competing platform for the genomewide
characterization of carcinogenesis. (Cancer Res Treat. 2003;35:304-313)
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