지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 98 - 102 (5page)
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초록· 키워드
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Purpose: DNA-PKcs is one of the DNA repair genes. It was recently found that hyperplasia and dysplasia of the intestinal mucosa and the production of aberrant crypt foci were developed in DNA-PKcs-null mice, and this suggests a suppressive role for DNA-PKcs in tumorigenesis.
Materials and Methods: To investigate the possible relationship between the clinico-pathologic characteristics and the survival of gastric cancer patients, the expression status of DNA-PKcs was determined in 279 consecutive gastric cancers. Immunohistochemical analysis was performed to evaluate the expression levels of DNA-PKcs protein by using the tissue array method.
Results: Out of 279 consecutive gastric cancers, 63 cases (22.6%) showed the loss of DNA-PKcs expression. The loss of DNA-PKcs expression was significantly associated with advanced cancer (p＜0.001), lymphatic invasion (p=0.001), lymph node metastasis (p=0.009), and advanced pTNM stage (p=0.009). Univariate survival analysis revealed that patients with the loss of DNA-PKcs expression had significantly poorer survival than those patients with intact DNA-PKcs expression (p=0.004). Moreover,the loss of DNA-PKcs expression was identified to correlate with a lower survival in the subgroup of stage I gastric cancer patients (p=0.037).
Conclusion: The loss of DNA-PKcs expression was found in 23% of human gastric cancers and this was identified to significantly correlate with poor patient survival, especially for stage I gastric cancer patients.
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참고문헌 (21)
참고문헌 신청
/ 1991 / Mutator phenotype may be required for multistage carcinogenesis 51 : 3075 ~ 9
/ 1994 / assembles on double-stranded DNA : 6904 ~ 8
/ 1995 / Absence of p350 subunit of DNAactivated protein kinase from a radiosensitive human cell line 267 : 1183 ~ 5
/ 1996 / Identification of a nonsense mutation in the carboxylterminalregion of DNA-dependent protein kinase catalyticsubunit in the scid mouse 93 : 10285 ~ 90
/ 1996 / In: Jackson SP. DNA damage detection by DNA dependent protein kinase and related enzymes. : 261 ~ 79
/ 1994 / assembles on double-stranded DNA : 6904 ~ 8
/ 1995 / Absence of p350 subunit of DNAactivated protein kinase from a radiosensitive human cell line 267 : 1183 ~ 5
/ 1996 / Identification of a nonsense mutation in the carboxylterminalregion of DNA-dependent protein kinase catalyticsubunit in the scid mouse 93 : 10285 ~ 90
/ 1996 / In: Jackson SP. DNA damage detection by DNA dependent protein kinase and related enzymes. : 261 ~ 79
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