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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 915 - 926 (12page)
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Purpose Patient-derived tumor xenografts (PDXs) can provide more reliable information about tumor biology than cell line models. We developed PDXs for epithelial ovarian cancer (EOC) that have histopathologic and genetic similarities to the primary patient tissues and evaluated their potential for use as a platform for translational EOC research.
Materials and Methods We successfully established PDXs by subrenal capsule implantation of primary EOC tissues into female BALB/C-nude mice. The rate of successful PDX engraftment was 48.8% (22/45 cases). Hematoxylin and eosin staining and short tandem repeat analysis showed histopathological and genetic similarity between the PDX and primary patient tissues.
Results Patients whose tumors were successfully engrafted in mice had significantly inferior overall survival when compared with those whose tumors failed to engraft (p=0.040). In preclinical tests of this model, we found that paclitaxel-carboplatin combination chemotherapy significantly deceased tumor weight in PDXs compared with the control treatment (p=0.013).
Moreover, erlotinib treatment significantly decreased tumor weight in epidermal growth factor receptor–overexpressing PDX with clear cell histology (p=0.023).
Conclusion PDXs for EOC with histopathological and genetic stability can be efficiently developed by subrenal capsule implantation and have the potential to provide a promising platform for future translational research and precision medicine for EOC.
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참고문헌 (22)
참고문헌 신청
Boone JD / 2015 / Ovarian and cervical cancer patient derived xenografts : the past, present, and future / Gynecol Oncol 138 : 486 ~ 491
Dobbin ZC / 2014 / Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer / Oncotarget 5 : 8750 ~ 8764
Duffy MJ / 2013 / The war on cancer: are we winning? / Tumour Biol 34 : 1275 ~ 1284
Elkas JC / 2002 / A human ovarian carcinoma murine xenograft model useful for preclinical trials / Gynecol Oncol 87 : 200 ~ 206
Hidalgo M / 2014 / Patient-derived xenograft models : an emerging platform for translational cancer research / Cancer Discov 4 : 998 ~ 1013
Dobbin ZC / 2014 / Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer / Oncotarget 5 : 8750 ~ 8764
Duffy MJ / 2013 / The war on cancer: are we winning? / Tumour Biol 34 : 1275 ~ 1284
Elkas JC / 2002 / A human ovarian carcinoma murine xenograft model useful for preclinical trials / Gynecol Oncol 87 : 200 ~ 206
Hidalgo M / 2014 / Patient-derived xenograft models : an emerging platform for translational cancer research / Cancer Discov 4 : 998 ~ 1013
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