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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 549 - 556 (8page)
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초록· 키워드
오류제보하기
Purpose: In order to elucidate the antitumor effect of
photodynamic therapy (PDT), using a derivative of the
photosensitizing agent hematoporphyrin (Photogem) and
a diode laser, the cell death of uterine cancer cell lines
(CaSki, HT3, HeLa, and SKOV-3), and mice transplanted
with TC-1 lung cancer cells, were evaluated.
Materials and Methods: The morphological changes,
MTT assay, flow cytometry, cytotoxicity and tumor
growth inhibition study were evaluated at various time
intervals after the PDT.
Results: The results showed that the survival rates of
each cell line decreased with time and dose response
after performing the PDT. Also, the PDT-induced damage
of cancer cells was almost entirely confined to necrosis
of the tumor cells in the early time courses. The irradiation
of CaSki cells in the presence of Photogem induced
plasma membrane disruption and cell shrinkage, indicating
the plasma membrane as the main target for
Photogem. In the in vivo experiment, significantly longer
survival and a significantly smaller tumor size were seen
over the time courses of the Photogem with irradiation
compared to the untreated control groups; resorption of
the tumor was also observed after the PDT treatment.
Conclusion: Collectively, our results indicated that Photogem
possesses anti-tumor effects, and necrosis- like
death, with plasma membrane damage, was postulated to
be the principal mechanism of the antitumor effect of the
PDT using Photogem. (Cancer Res Treat. 2003;35:549-556)
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