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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 24 - 31 (8page)
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초록· 키워드
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Purpose The present study evaluated whether oral supplementation with a branched-chain amino acid (BCAA) improves the biochemical and amino acid profiles of liver tumor patients undergoing radiotherapy.
Materials and Methods Patients were randomly assigned to one of 2 groups: a group given oral supplementation with BCAA granules (LIVACT granules; Samil Pharm Co., Korea, each granule containing Lisoleucine 952 mg, L-leucine 1,904 mg, and L-valine 1,144 mg) during radiotherapy, or a placebo group. Physical and biochemical examinations and measurements, including subjective symptoms, Child-Pugh class, body mass index, plasma albumin concentration, and plasma amino acid profiles were monitored.
Results Fifty were enrolled between November 2005 and November 2006. We also analyzed data from 37 hepatocellular carcinoma (HCC) patients in order to evaluate a more homogenous group. The two groups of patients were comparable in terms of age, gender, Child-Pugh score, and underlying hepatitis virus type. Serum albumin, total protein, liver enzymes, and cholesterol showed a tendency to increase in the BCAA group. In this group, the percentage of cases that reverted to normal serum albumin levels between 3 and 10 weeks after administration of BCAA was significantly higher (41.18%) than in the placebo group (p=0.043).
Conclusion Oral supplementation with a BCAA preparation seems to help HCC patients undergoing radiotherapy by increasing the BCAA concentration.
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참고문헌 (26)
참고문헌 신청
Nijveldt RJ / 2001 / Major liver resection results in a changed plasma amino acid pattern as reflected by a decreased Fischer ratio which improves by bactericidal/permeability increasing protein / Liver 21:56~63
Togo S / 2005 / Usefulness of granular BCAA after hepatectomy for liver cancer complicated with liver cirrhosis / Nutrition 21:480~486
Poon RT / 2004 / Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial / Aliment Pharmacol Ther 19:779~788
/ / Annual report on the cause of death statistics [Internet]. Daejeon: Korea National Statistical Office; 2009 [cited 2010 Mar 4]
Cheng JC / 2002 / Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: clinical manifestation and dosimetric description / Radiother Oncol 63 : 4
Togo S / 2005 / Usefulness of granular BCAA after hepatectomy for liver cancer complicated with liver cirrhosis / Nutrition 21:480~486
Poon RT / 2004 / Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial / Aliment Pharmacol Ther 19:779~788
/ / Annual report on the cause of death statistics [Internet]. Daejeon: Korea National Statistical Office; 2009 [cited 2010 Mar 4]
Cheng JC / 2002 / Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: clinical manifestation and dosimetric description / Radiother Oncol 63 : 4
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