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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 962 - 969 (8page)
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초록· 키워드
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Purpose Previous studies examining the relationship between time to treatment and survival outcome in breast cancer have shown inconsistent results. The aim of this study was to analyze the overall impact of delay of treatment initiation on patient survival and to determine whether certain subgroups require more prompt initiation of treatment.
Materials and Methods This study is a retrospective analysis of stage I-III patients who were treated in a single tertiary institution between 2005 and 2008. Kaplan-Meier survival analysis and Cox proportional hazards regression model were used to evaluate the impact of interval between diagnosis and treatment initiation in breast cancer and various subgroups.
Results A total of 1,702 patients were included. Factors associated with longer delay of treatment initiation were diagnosis at another hospital, medical comorbidities, and procedures performed before admission for surgery. An interval between diagnosis and treatment initiation as a continuous variable or with a cutoff value of 15, 30, 45, and 60 days had no impact on disease-free survival (DFS). Subgroup analyses for hormone-responsiveness, triple-negative breast cancer, young age, clinical stage, and type of initial treatment showed no significant association between longer delay of treatment initiation and DFS.
Conclusion Our results show that an interval between diagnosis and treatment initiation of 60 days or shorter does not appear to adversely affect DFS in breast cancer.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Brazda A / 2010 / Delays in time to treatment and survival impact in breast cancer / Ann Surg Oncol 17(Suppl 3):291~296
McLaughlin JM / 2012 / Effect on survival of longer intervals between confirmed diagnosis and treatment initiation among low-income women with breast cancer / J Clin Oncol 30:4493~4500
Mujar M / 2013 / Delays in time to primary treatment after a diagnosis of breast cancer : does it impact survival? / Prev Med 56:222~224
Shin DW / 2013 / Delay to curative surgery greater than 12 weeks is associated with increased mortality in patients with colorectal and breast cancer but not lung or thyroid cancer / Ann Surg Oncol 20:2468~2476
Smith EC / 2013 / Delay in surgical treatment and survival after breast cancer diagnosis in young women by race/ethnicity / JAMA Surg 148:516~523
McLaughlin JM / 2012 / Effect on survival of longer intervals between confirmed diagnosis and treatment initiation among low-income women with breast cancer / J Clin Oncol 30:4493~4500
Mujar M / 2013 / Delays in time to primary treatment after a diagnosis of breast cancer : does it impact survival? / Prev Med 56:222~224
Shin DW / 2013 / Delay to curative surgery greater than 12 weeks is associated with increased mortality in patients with colorectal and breast cancer but not lung or thyroid cancer / Ann Surg Oncol 20:2468~2476
Smith EC / 2013 / Delay in surgical treatment and survival after breast cancer diagnosis in young women by race/ethnicity / JAMA Surg 148:516~523
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