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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,045 - 1,055 (11page)
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Purpose The optimal treatment strategy for locally advanced pancreatic cancer (LAPC), particularly the role of concurrent chemoradiotherapy (CCRT), remains debatable. We compared the clinical outcomes of CCRT and palliative chemotherapy alone (CA) in patients with unresectable LAPC.
Materials and Methods Patients with LAPC who were consecutively treated between 2003 and 2010 were included.
Resectability was evaluated according to National Comprehensive Cancer Network ver.
1.2012. The clinical outcomes for each treatment group (CCRT vs. CA) were evaluated retrospectively.
Results Sixty-three patients (58.9%) and 44 patients (41.1%) were treated with CCRT and CA, respectively. The CCRT cohort included patients who were treated with CCRT with or without chemotherapy backbone (CCRT alone, induction chemotherapy-CCRT, CCRT-maintenance chemotherapy, and induction-CCRT-maintenance chemotherapy). Median progression-free survival (PFS) and overall survival (OS) of all patients were 7.2 months and 13.1 months.
PFS of the CCRT and CA groups was 9.0 months and 4.4 months, respectively (p=0.020).
OS of the CCRT and CA groups was 15.4 months and 9.3 months, respectively (p=0.011).
In multivariate analysis, the adjusted hazard ratio of CCRT was 0.536 (p=0.003) for OS and 0.667 (p=0.078) for PFS. Although the pattern of failure was similar in the CCRT and CA groups, the times to both local and distant failure were significantly longer in the CCRT group.
Conclusion In patients with unresectable LAPC, those who underwent CCRT during their entire treatment courses had longer OS than patients treated with chemotherapy alone.
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참고문헌 (20)
참고문헌 신청
Kris MG / 2010 / Clinical cancer advances 2010 : annual report on progress against cancer from the American Society of Clinical Oncology / J Clin Oncol 28:5327~5347
Mayahara H / 2012 / Salvage chemoradiotherapy after primary chemotherapy for locally advanced pancreatic cancer : a single-institution retrospective analysis / BMC Cancer 12:609
Moertel CG / 1981 / Therapy of locally unresectable pancreatic carcinoma : a randomized comparison of high dose(6000 rads)radiation alone, moderate dose radiation(4000 rads + 5-fluorou-racil), and high dose radiation + 5-fluorouracil : The Gastrointestinal Tumor Study Group / Cancer 48:1705~1710
Hariharan D / 2008 / Analysis of mortality rates for pancreatic cancer across the world / HPB(Oxford) 10:58~62
Treatment of locally unresectable carcinoma of the pancreas : comparison of combined-modality therapy(chemotherapy plus radiotherapy)to chemotherapy alone / 1988 / Gastrointestinal Tumor Study Group / J Natl Cancer Inst 80:751~755
Mayahara H / 2012 / Salvage chemoradiotherapy after primary chemotherapy for locally advanced pancreatic cancer : a single-institution retrospective analysis / BMC Cancer 12:609
Moertel CG / 1981 / Therapy of locally unresectable pancreatic carcinoma : a randomized comparison of high dose(6000 rads)radiation alone, moderate dose radiation(4000 rads + 5-fluorou-racil), and high dose radiation + 5-fluorouracil : The Gastrointestinal Tumor Study Group / Cancer 48:1705~1710
Hariharan D / 2008 / Analysis of mortality rates for pancreatic cancer across the world / HPB(Oxford) 10:58~62
Treatment of locally unresectable carcinoma of the pancreas : comparison of combined-modality therapy(chemotherapy plus radiotherapy)to chemotherapy alone / 1988 / Gastrointestinal Tumor Study Group / J Natl Cancer Inst 80:751~755
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