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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 72 - 77 (6page)
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Purpose Capecitabine is known to increase mean corpuscular volume (MCV). To define the incidenceof capecitabine-induced macrocytosis and its association with chemotherapy outcomes,we investigated data of 89 patients with advanced gastric cancer (AGC) who were enrolledin a randomized chemotherapy trial involving capecitabine.
Materials and MethodsChemotherapy-naïve AGC patients were treated with capecitabine (1,000 mg/m2/day ondays 1-14) plus cisplatin (75 mg/m2 on day 1), with or without epirubicin (50 mg/m2 on day1). Complete blood counts including MCV were measured at baseline and on day 1 of each3-week chemotherapy course. Macrocytosis was defined as a MCV increase > 10 fL frombaseline. Multivariate Cox proportional hazards models were used for analysis of the impactof clinical and MCV values on chemotherapy outcomes.
ResultsAt baseline, the mean MCV was 88.2 fL (normal range, 80 to 100 fL). During chemotherapy,MCV increased in a dose-dependent manner with a mean increase of 11.3 fL. MCV elevationafter capecitabine treatment in 74 patients (90%) and 44 patients (42%) developed macrocytosis.
Results of multivariate analysis showed that development of macrocytosis wasindependent of baseline hemoglobin level, liver metastasis, performance status, or liverfunction. The number of chemotherapy cycles showed strong association with developmentof macrocytosis and hematologic adverse events. In addition, a significant association wasobserved between macrocytosis and clinical response or survival.
ConclusionMacrocytosis developed with more frequent and prolonged use of capecitabine. It is possiblethat association with treatment outcomes warrants further investigation.
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참고문헌 (14)
참고문헌 신청
Allegra CJ / 2002 / Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer / J Clin Onco
Borner MM / 2002 / Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin : a randomised crossover trial in advanced col
Karvellas CJ / 2004 / Effect of capecitabine on mean corpuscular volume in patients with metastatic breast cancer / Am J Clin Oncol 27 : 364 ~ 368
Midgley R / 2009 / Capecitabine: have we got the dose right? / Nat Clin Pract Oncol 6 : 17 ~ 24
Okines A / 2008 / Capecitabine in gastric cancer / Drugs Today(Barc) 44 : 629 ~ 640
Borner MM / 2002 / Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin : a randomised crossover trial in advanced col
Karvellas CJ / 2004 / Effect of capecitabine on mean corpuscular volume in patients with metastatic breast cancer / Am J Clin Oncol 27 : 364 ~ 368
Midgley R / 2009 / Capecitabine: have we got the dose right? / Nat Clin Pract Oncol 6 : 17 ~ 24
Okines A / 2008 / Capecitabine in gastric cancer / Drugs Today(Barc) 44 : 629 ~ 640
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