지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Biomarkers are characteristic biological properties that
can be detected and measured in a variety of biological
matrices in the human body, including the blood and tissue,
to give an indication of whether there is a threat of disease,
if a disease already exists, or how such a disease may
develop in an individual case. Along the continuum from
exposure to clinical disease and progression, exposure,
internal dose, biologically effective dose, early biological
effect, altered structure and/or function, clinical disease,
and disease progression can potentially be observed and
quantified using biomarkers. While the traditional discovery
of biomarkers has been a slow process, the advent of
molecular and genomic medicine has resulted in explosive
growth in the discovery of new biomarkers. In this review,
issues in evaluating biomarkers will be discussed and the
biomarkers of environmental exposure, early biologic effect,
and susceptibility identified and validated in epidemiological
studies will be summarized. The spectrum of genomic
approaches currently used to identify and apply biomarkers
and strategies to validate genomic biomarkers will also be
discussed.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Boffetta P / 2006 / Serum cotinine level as predictor of lung cancer risk / Cancer Epidemiol Biomarkers Prev 15 (6) : 1184 ~ 1188
Chatterjee SK / 2005 / Cancer biomarkers:Knowing the present and predicting the future / Future Oncol 1 (1) : 37 ~ 50
Giordano TP / 2007 / Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virus / JAMA 297 (18) : 2010 ~ 2017
Golub TR / 1999 / Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring / Science 286 (5439) : 531 ~ 537
Gunter MJ / 2007 / Leukocyte polycyclic aromatic hydrocarbon-DNA adduct formation and colorectal adenoma / Carcinogenesis 28 (7) : 1426 ~ 1429
Chatterjee SK / 2005 / Cancer biomarkers:Knowing the present and predicting the future / Future Oncol 1 (1) : 37 ~ 50
Giordano TP / 2007 / Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virus / JAMA 297 (18) : 2010 ~ 2017
Golub TR / 1999 / Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring / Science 286 (5439) : 531 ~ 537
Gunter MJ / 2007 / Leukocyte polycyclic aromatic hydrocarbon-DNA adduct formation and colorectal adenoma / Carcinogenesis 28 (7) : 1426 ~ 1429
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