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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 261 - 266 (6page)
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Purpose: The objective of this phase II study was to
assess the clinical antitumor activity and toxicities of
docetaxel and cisplatin chemotherapy, in patients with
locally advanced and metastatic, recurrent squamous
cell carcinomas of the head and neck (SCCHN).
Materials and Methods: All eligible patients with locally
advanced and metastatic, recurrent SCCHN had received
two courses of chemotherapy followed by repeated head
and neck examinations and computed tomography.
Patients who had received prior chemotherapy with taxanes
were ineligible. If the patients achieved a response
(either CR or PR), they received one more course of
chemotherapy prior to undergoing definitive local treatment.
The combination chemotherapy consisted of
docetaxel, 70 mg/m2, and cisplatin, 75 mg/m2, on day 1,
with the cycles repeated every 3~4 weeks.
Results: All 32 patients were assessable for response
and toxicity analyses. The most common grade 3/4
adverse event was neutropenia, which occurred in 11%
of cases. No febrile neutropenia was noticed. The other
grade 3/4 adverse events included: anemia (2%) and
stomatitis (3%). The response rate in patients with locally
advanced cancer was 19/21 (90%). Fifteen patients (71%)
achieved a CR and 4 (19%) a PR. Out of the 4 patients
presenting with a distant metastatic disease, 1 each achieved
CR and PR, with 2 stable disease (SD). Out of the
7 patients with a recurrence at a distant site, 1 each achieved
PR and SD, and 5 (71%) had a progression of the
disease (PD). The overall response rate was 22/32 (69%).
Conclusion: Docetaxel plus cisplatin is an effective
regimen with an acceptable toxicity profile. This regimen
may offer high antitumor activity on short outpatient
administration, with a low incidence of severe toxicity.
(Cancer Res Treat. 2003;35:261-266)
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