지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: We evaluated the association between common carotid artery intima-media thickness (CCA-IMT), brachialankle pulse wave velocity (baPWV), carotid plaque, and peripheral arterial disease (PAD) as indicators of macroangiopathy and diabetic retinopathy as an indicator of microangiopathy in type 2 diabetic patients.
Methods: We analyzed 605 type 2 diabetic patients registered at a public health center in Korea. Following overnight fasting, venous blood and urine samples were collected and analyzed. The CCA-IMT, levels of carotid plaque, baPWV,and ankle-brachial index (ABI) of the subjects were assessed. We used non-mydriatic fundus photography to diagnose diabetic retinopathy. Multiple logistic regression analyses were used to evaluate the association between macroangiopathy and diabetic retinopathy. CCA-IMT and baPWV were divided into tertiles: CCA-IMT, 0.39 to 0.65 mm,0.66 to 0.78 mm, and 0.79 to 1.30 mm; baPWV, 9.9 to 15.8 m/s, 15.9 to 18.9 m/s, and 19.0 to 38.0 m/s.
Results: The association between baPWV and diabetic retinopathy remained significant after adjustment, with an increasing odds ratio (OR) in the second tertile (OR, 2.41; 95% confidence interval [CI], 1.27 to 4.55) and the third tertile (OR, 4.63;95% CI, 2.33 to 9.21). No significant differences were observed in carotid plaque, PAD, and each tertile of CCA-IMT.
Conclusions: BaPWV was associated with diabetic retinopathy, while CCA-IMT, carotid plaque, and PAD were not. This study suggests that the association between macroangiopathy and microangiopathy may be attributable to functional processes rather than structural processes within the vascular system.
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참고문헌 (35)
참고문헌 신청
Ogawa O / 2005 / Arterial stiffness is associated with diabetic retinopathy in type 2 diabetes / Diabetes Res Clin Pract 68(2):162~166
Ogawa O / 2008 / Diabetic retinopathy is associated with pulse wave velocity, not with the augmentation index of pulse waveform / Cardiovasc Diabetol 7:11
Friedewald WT / 1972 / Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge / Clin Chem 18(6):499~502
Levey AS / 1999 / A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group / Ann Intern Med 130(6):461~470
1991 / Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification / Ophthalmology 98(5):786~806
Ogawa O / 2008 / Diabetic retinopathy is associated with pulse wave velocity, not with the augmentation index of pulse waveform / Cardiovasc Diabetol 7:11
Friedewald WT / 1972 / Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge / Clin Chem 18(6):499~502
Levey AS / 1999 / A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group / Ann Intern Med 130(6):461~470
1991 / Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification / Ophthalmology 98(5):786~806
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