경기도 일개 지역사회 대표집단에서 고호모시스테인혈증의 유병률 및 관련요인에 대한 단면조사연구

김수정; 송미숙; 이순영; 임경숙; 강연지

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자료유형: 학술저널

저자정보: 김수정 송미숙 이순영 임경숙 강연지

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제42권 제5호

발행연도: 2009.1

수록면: 337 - 342 (6page)

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연구주제

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연구배경

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연구방법

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연구결과

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Background : Many previous studies have shown that elevated homocysteine in the serum is a well known risk factor for cardiovascular disease and this is associated with other risk factors for cardiovascular disease, but any Korean data on this is limited. Objectives : This study aimed to calculate the prevalence of hyperhomocysteinemia and to analyze the relation between elevated homocysteine and the lifestyle factors of Korean adults. Methods : We conducted a cross-sectional survey that included 650 men and 743 women (age range, 20 to 79 years) who were residents of Gwangju City in Gyeonggi-do. These subjects participated in the health interview and examination survey from November to December 2005. The total homocysteine, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride in the serum were measured. All the participants had their body composition measured such as height and weight, and we obtained health-related behavioral information through the self-entry questionnaire. Results : Very right-handed skewed distributions of homocysteine were shown in men and women. The prevalence of hyperhomocysteinemia was 22.6% in men and 13.7% in women in Gwangju city. On the multiple logistic regression analysis, hyperhomocysteinemia was associated with age (OR=1.02, 95% CI=1.01-1.04), male gender (OR=1.60, 95% CI=1.02-2.52), severe general physical activity (OR=0.32, 95% CI=0.15-0.69) and nutrient consumption (OR=0.49, 95% CI=0.31-0.76). Conclusions : There is a great prevalence of hyperhomocysteinemia in adults of Gwangju City, Korea and it was associated with both genetic factors and lifestyle risk factors. This study can suggest that comprehensive lifestyle modification is needed in order to diminish the prevalence of hyperhomocysteinemia and to prevent CVD.

#Adults #Cross sectional survey #Homocysteine #Hyperhomocysteinemia #Prevalence #Korea

참고문헌 (24)

참고문헌 신청

Arnesen E / 1995 / Serum total homocysteine and coronary heart disease / Int J Epidemiol 24 (4) : 704 ~ 709

Boushey CJ / 1995 / A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes / JAMA 274 (13)

Caldera A / 2002 / Hyperhomocysteinemia and transplant coronary artery disease / Transplantation 74 (10) : 1359 ~ 1364

Duell PB / 1997 / Homocyst(e)ine: An important risk factor for atherosclerotic vascular disease / Curr Opin Lipidol 8 (1) : 28 ~ 34

Gaume V / 2005 / Physical training decreases total plasma homocysteine and cysteine in middle-aged subjects / Ann Nutr Metab 49 (2) : 125 ~ 131

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