Relationship Between Serum Concentrations of Organochlorine Pesticides and Metabolic Syndrome Among Non-Diabetic Adults

박선균; 손효경; 이성국; Ph.D.; 강정호; 장윤석; David R.Jacobs Jr.; 이덕희

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자료유형: 학술저널

저자정보: 박선균 손효경 이성국 Ph.D. 강정호 장윤석 David R.Jacobs Jr. 이덕희

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제43권 제1호

발행연도: 2010.1

수록면: 1 - 8 (8page)

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Objectives: This study was performed to investigate if organochlorine pesticides (OCPs) were associated with metabolic syndrome and insulin resistance among non-diabetes. Methods: Among subjects who participated in a community-based health survey, 50 non-diabetic subjects with metabolic syndrome and 50 normal controls were selected. Insulin resistance was measured by the homeostasis model assessment (HOMA-IR). Eight OCPs were selected. Results: After adjusting for confounders except for body mass index (BMI), beta-hexachlorocyclohexane (β-HCH) and heptachlor epoxide were positively associated with metabolic syndrome. Odds ratios across tertiles of β-HCH and heptachlor epoxide were 1.0, 3.2 and 4.4, and 1.0, 4.0 and 6.0, respectively (p for trend = 0.01 and <0.01). After additional adjustment for body mass index (BMI), heptachlor epoxide still showed an increasing trend with adjusted odds ratios of 1.0, 4.1, and 4.6 (p for trend = 0.10). When the five components of metabolic syndrome (with the definition of high fasting glucose (≥100 mg/dL)) were separately analyzed, all components were positively, but not significantly,associated with heptachlor epoxide. As the serum concentration of heptachlor epoxide increased, HOMA-IR increased significantly in subjects with metabolic syndrome even after adjusting for BMI (p value <0.05 and <0.01). Conclusions: Despite the small sample size, this study suggests that the background exposure to some OCPs may be associated with metabolic syndrome.

#Organochlorine compounds #Environmental pollutants #Persistent organic pollutants #Metabolic syndrome X #Insulin resistance #Obesity

참고문헌 (22)

참고문헌 신청

Agency for Toxic Substances and Disease Registry / / Heptachlor and Heptachlor Epoxide

Allsopp M / / A review of persistent organic pollutant levels in South and Southeast Asia and Oceania

CDC / / Third national report on human exposure to environmental chemicals

Fendick EA / 1990 / Ecological toxicology and human health effects of heptachlor / Rev Environ Contam Toxicol 111 : 61 ~ 142

Fisher BE / 1999 / Most unwanted / Environ Health Perspect 107 (1) : A18 ~ A23

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