A Survey on the Status of Hepatitis E Virus Infection Among Slaughterhouse Workers in South Korea

Hyun-Sul Lim; Byung-Seok Kim; Kwan Lee; Young-Sun Min; Young-Sil Yoon; Hye-Sook Jeong

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자료유형: 학술저널

저자정보: Hyun-Sul Lim Byung-Seok Kim Kwan Lee Young-Sun Min Young-Sil Yoon Hye-Sook Jeong

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제48권 제1호

발행연도: 2015.1

수록면: 53 - 61 (9page)

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Objectives: The seroprevalence of hepatitis E virus (HEV) among high-risk groups overseas is high, but studies in these groups are rare in South Korea. We conducted the present study from April to November 2012 to obtain data on the seroprevalence and associated risk factors for HEV among slaughterhouse workers in South Korea. Methods: Slaughterhouse workers from 80 workplaces nationwide were surveyed in South Korea in 2012. The subjects comprised 1848 cases: 1434 slaughter workers and 414 residual products handlers. By visiting 80 slaughterhouses, which were mixed with 75 of which also performed residual products handling, we conducted a questionnaire survey for risk factors and obtained blood samples in order to determine the seropositivity and seroprevalence of HEV. Anti-HEV IgG and IgM were measured using HEV IgG and IgM enzyme-linked immunospecific assay kits and HEV antigen was measured by reverse transcription polymerase chain reaction (RT-PCR). Results: The seropositivity of anti-HEV IgG was 33.5% (slaughter workers 32.8% and residual products handlers 36.2%), and among the seropositive individuals the seroprevalence of anti-HEV IgM was 0.5% (slaughter workers 0.5%, residual products handlers 0.7%). The response rate of HEV-antigen as measured by RT-PCR was 0.2%. Risk factors significantly related to anti-HEV IgG seropositivity were age, sex , and working duration (slaughter workers only). Conclusions: There were significant risk factors (sex, age, and working duration) for HEV identified in our study. All three positive casesfor HEV-antigen by RT-PCR were related to pig slaughter but without statistical significance. To prevent HEV, an educational programand working guidelines may be needed for high risk groups.

#Hepatitis E #Slaughterhouse #Zoonoses #Seroprevalence #Risk factors

참고문헌 (26)

참고문헌 신청

Ahn JM / 2005 / Identification of novel human hepatitis E virus (HEV) isolates and determination of the seroprevalence of HEV in Korea / J Clin Microbiol 43 (7) : 3042 ~ 3048

Boxall E / 2006 / Transfusion-transmitted hepatitis E in a ‘nonhyperendemic’country / Transfus Med 16 (2) : 79 ~ 83

Byun KS / 1996 / Prevalences of IgG and IgM anti-HEV in patients with acute hepatitis of unknown causes and healthy adults in Korea / Korean J Gastroenterol 28 (5) : 661 ~ 66

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