지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Although sound intensity is considered as one of important factors in auditory processing, its neural mechanism in auditory neurons with limited dynamic range of firing rates is still unclear. In this study, we examined the effect of sound intensity adaptation on the change of glucose metabolism in a rat brain using [F-18] micro positron emission tomography (PET) neuroimaging technique. In the experiment, broadband white noise sound was given for 30 minutes after the [F-18]FDG injection in order to explore the functional adaptation of rat brain into the sound intensity levels. Nine rats were scanned with four different sound intensity levels: 40 dB, 60 dB, 80 dB, 100 dB sound pressure level (SPL) for four weeks. When glucose uptake during the adaptation of a high intensity sound level (100 dB SPL) was compared with that during adaptation to a low intensity level (40 dB SPL) in the experiment, the former induced a greater uptake at bilateral cochlear nucleus, superior olivary complexes and inferior colliculi in the auditory pathway. Expectedly, the metabolic activity in those areas linearly increased as the sound intensity level increased. In contrast, significant decrease interestingly occurred in the bilateral auditory cortices: The activities of auditory cortex proportionally decreased with higher sound intensities. It may reflect that the auditory cortex actively down-regulates neural activities when the sound gets louder.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
B. Canlon / 1983 / Acoustic stimulation alters deoxyglucose uptake in the mouse cochlea and inferior colliculus / Hear Res 10 : 217 ~ 226
D. P. Jang / 2009 / Effects of fluoxetine on the rat brain in the forced swimming test: a [F-18]FDG micro-PET imaging study / Neurosci Lett 451 : 60 ~ 64
D. P. Jang / 2009 / Neural responses of rats in the forced swimming test: [F-18]FDG micro PET study / Behav Brain Res 203 : 43 ~ 47
E. Christopher Kirk / 2003 / Protection from acoustic trauma is not a primary function of the medial olivocochlear efferent system / J Assoc Res Otolaryngol 4 : 445 ~ 465
F. E. Olucha / 1997 / Activation of proto-oncogene c-fos in the auditory tract of rats stimulation with wide-band noise / Acta Otorrinolaringol Esp 48 : 85 ~ 92
D. P. Jang / 2009 / Effects of fluoxetine on the rat brain in the forced swimming test: a [F-18]FDG micro-PET imaging study / Neurosci Lett 451 : 60 ~ 64
D. P. Jang / 2009 / Neural responses of rats in the forced swimming test: [F-18]FDG micro PET study / Behav Brain Res 203 : 43 ~ 47
E. Christopher Kirk / 2003 / Protection from acoustic trauma is not a primary function of the medial olivocochlear efferent system / J Assoc Res Otolaryngol 4 : 445 ~ 465
F. E. Olucha / 1997 / Activation of proto-oncogene c-fos in the auditory tract of rats stimulation with wide-band noise / Acta Otorrinolaringol Esp 48 : 85 ~ 92
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