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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Explant culture condition of dorsal root ganglion have been used to investigate the pathophysiology of peripheral nerve injury, while applying for the various clinical symptom such as trauma, pressure, and stretch. However, explant culture is usually contaminated by mitotic cells, which may observed as a newly divided cells including fibroblast or glia. The mitotic cells could be able to interrupt and change the cell signaling that make it difficult to avoid detrimental effects during the experiments. To eliminate mitotic cells, anti-mitotic reagents like mixture of uridine and 5-fluorodeoxyuridine or cytosine arabinoside were added to the cultures on the following day, but there is no research that investigate viability of anti-mitotic reagent in dorsal root ganglion explant culture. In this study, we investigate inhibition effect of cytosine arabinoside to mitotic cells in dorsal root ganglion explant culture. Also we visualized and analyzed anti-mitotic effect and toxicity of cytosine arabinoside in various concentration condition. This dorsal root ganglion explant culture condition can be applied to research that effect and mechanism of various stimulation and chemical application which affect peripheral nerve regeneration.
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참고문헌 (13)
참고문헌 신청
A. M. Kenney / 1998 / Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat do
C. G. Besirli / 2003 / Cytosine arabinoside rapidly activates Bax-independent death pathway in sympathetic neurons / Cell Death Differ 10 : 1045 ~ 1058
D. S. Park / 1996 / Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons / J. Biol, Chem 271
E. Gutmann / 1942 / The rate of regeneration of nerve / J. Exp. Biol 19 : 14 ~ 44
G. Evans-Jones / 2003 / Congenital brachial palsy: incidence, causes, and outcome in the United Kingdom and Republic of Ireland / Arch. Dis. Child. Fetal Neonatal ED. 88 : F1
C. G. Besirli / 2003 / Cytosine arabinoside rapidly activates Bax-independent death pathway in sympathetic neurons / Cell Death Differ 10 : 1045 ~ 1058
D. S. Park / 1996 / Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons / J. Biol, Chem 271
E. Gutmann / 1942 / The rate of regeneration of nerve / J. Exp. Biol 19 : 14 ~ 44
G. Evans-Jones / 2003 / Congenital brachial palsy: incidence, causes, and outcome in the United Kingdom and Republic of Ireland / Arch. Dis. Child. Fetal Neonatal ED. 88 : F1
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