지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 294 - 297 (4page)
이용수
초록· 키워드
오류제보하기
Numerical and structural chromosomal abnormalities are common in hematological malignancies. Near-triploidy (58-80 chromosomes) is a numerical abnormality observed in 3% of adult cases of acute lymphoblastic leukemia. Near-triploidy is rare in myeloid lineage hematologic malignancies and compared to near-triploidy in lymphoid malignancies, neartriploidy in myeloid malignancies is associated with poor outcomes. Few studies on neartriploidy in myelodysplastic syndrome (MDS) have been reported, and the clinicopathologic significance of this condition is still unclear. Here, we report a novel case of MDS with near-triploidy and multiple structural chromosomal abnormalities: del(5q) combined with del(1p) and del(13q). These abnormalities were detected by cytogenetic analysis with array comparative genomic hybridization (CGH). Our results suggest that array CGH can be a useful tool for detecting chromosomal abnormalities in patients with MDS.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Acar H / 2001 / Hyperdiploid karyotype in a childhood MDS patient / Clin Lab Haematol 23 : 255 ~ 258
Bacher U / 2009 / The impact of cytomorphology, cytogenetics, molecular genetics, and immunophenotyping in a comprehensive diagnostic workup of myelodysplastic syndromes / C
Hu J / 2007 / Exploiting noise in array CGH data to improve detection of DNA copy number change / Nucleic Acids Res 35 : e35 ~
Iyer RV / 2004 / Massive hyperdiploidy and tetraploidy in acute myelocytic leukemia and myelodysplastic syndrome / Cancer Genet Cytogenet 148 : 29 ~ 34
Kawankar N / 2011 / Cytogenetic abnormalities in myelodysplastic syndrome: an overview / Hematology 16 : 131 ~ 138
Bacher U / 2009 / The impact of cytomorphology, cytogenetics, molecular genetics, and immunophenotyping in a comprehensive diagnostic workup of myelodysplastic syndromes / C
Hu J / 2007 / Exploiting noise in array CGH data to improve detection of DNA copy number change / Nucleic Acids Res 35 : e35 ~
Iyer RV / 2004 / Massive hyperdiploidy and tetraploidy in acute myelocytic leukemia and myelodysplastic syndrome / Cancer Genet Cytogenet 148 : 29 ~ 34
Kawankar N / 2011 / Cytogenetic abnormalities in myelodysplastic syndrome: an overview / Hematology 16 : 131 ~ 138
이 논문의 저자 정보
최근 본 자료
댓글(0)
0