지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 10 - 18 (9page)
이용수
초록· 키워드
오류제보하기
Background: Antenatal screening for Down’s syndrome has been developed and improved over the past 20 yr. Recently, integrated test, which combines the first and second trimester markers has shown the highest detection rate (DR) and lowest false positive rate (FPR) among Down’s syndrome screening tests currently in use. The purposes of this study were to evaluate the screening performance of integrated test and to compare the results with triple test studies in Korea.
Methods: The study population consisted of Korean pregnant women who underwent triple or integrated test between April 2005 and December 2008. Triple test was performed using measurements of alpha-fetoprotein (AFP), unconjugated estriol (uE3), and human chorionic gonadotropin (hCG)in the second trimester. Integrated test was performed using nuchal translucency (NT) by ultrasonography and pregnancy-associated plasma protein A (PAPP-A) from maternal serum in the first trimester, and AFP, uE3, hCG, and inhibin-A in the second trimester. The screening performance of each test was evaluated by DR and FPR.
Results: Twenty-seven Down’s syndrome pregnancies were confirmed in women screened by triple (N=6,736) or integrated test (N=7,688). At 1:100, 1:270, and 1:300 of risk cutoff, triple test showed 45%, 73%, and 73% of DR and 4.7%, 11.2%, and 12.4% of FPR, respectively. At 1:100,1:150, and 1:300 of risk cutoff, integrated test showed 63%, 69%, and 75% of DR and 1.5%, 1.9%, and 3.0% of FPR, respectively.
Conclusions: Integrated test showed higher DR and lower FPR, demonstrating better screening performance than triple test.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
ACOG Committee on Practice Bulletins / 2007 / ACOG Practice Bulletin No. 77: screening for fetal chromosomal abnormalities / Obstet Gynecol 109 : 217 ~ 227
ACOG educational bulletin / 1996 / Maternal serum screening. Number 228, September 1996 (replaces no. 154, April 1991) / Int J Gynaecol Obstet 55 : 299 ~ 308
Bindra R / 2002 / One-stop clinic for assessment of risk for trisomy 21 at 11-14 weeks: a prospective study of 15,030 pregnancies / Ultrasound Obstet Gynecol 20 : 219 ~ 225
Brizot ML / 1994 / Maternal serum pregnancy-associated plasma protein A and fetal nuchal translucency thickness for the prediction of fetal trisomies in early pregnancy / Obs
Caron L / 1999 / Frequencies of chromosomal abnormalities at amniocentesis: over 20 years of cytogenetic analyses in one laboratory / Am J Med Genet 82 : 149 ~ 154
ACOG educational bulletin / 1996 / Maternal serum screening. Number 228, September 1996 (replaces no. 154, April 1991) / Int J Gynaecol Obstet 55 : 299 ~ 308
Bindra R / 2002 / One-stop clinic for assessment of risk for trisomy 21 at 11-14 weeks: a prospective study of 15,030 pregnancies / Ultrasound Obstet Gynecol 20 : 219 ~ 225
Brizot ML / 1994 / Maternal serum pregnancy-associated plasma protein A and fetal nuchal translucency thickness for the prediction of fetal trisomies in early pregnancy / Obs
Caron L / 1999 / Frequencies of chromosomal abnormalities at amniocentesis: over 20 years of cytogenetic analyses in one laboratory / Am J Med Genet 82 : 149 ~ 154
이 논문의 저자 정보
최근 본 자료
댓글(0)
0