지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 99 - 101 (3page)
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Hereditary hemolytic anemia comprises a group of disorders in which red blood cells are destroyed faster than they are produced in the bone marrow; various hereditary factors can cause this condition, including production of defective Hb and erythrocyte membrane. Recently, we identified Hb Koriyama, a rare Hb variant that was undetectable in Hb electrophoresis and stability tests, in a patient with severe hemolytic anemia. This is the first study to show the nucleotide-level sequence variations in Hb Koriyama. On the basis of our results, we conclude that unstable Hb may not be detectable by conventional Hb electrophoresis or stability tests. Thus, we suggest further genetic workup in cases of unexplained hereditary hemolytic anemia.
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참고문헌 (8)
참고문헌 신청
Giardine B / 2007 / HbVar database of human hemoglobin variants and thalassemia mutations: 2007 update / Hum Mutat 28 : 206 ~
Hardison RC / 2002 / HbVar: a relational database of human hemoglobin variants and thalassemia mutations at the globin gene server / Hum Mutat 19 : 225 ~ 233
Kawata R / 1988 / Hyperunstable hemoglobin Koriyama anti-Hb Gun Hill insertion of five residues in the beta chain / Hemoglobin 12 : 311 ~ 321
Natarajan K / 2010 / Disorders of hemoglobin structure: sickle cell anemia and related abnormalities, In Williams Hematology. 8th ed / McGraw-Hill
Patrinos GP / 2004 / Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies / Nucleic Acids R
Hardison RC / 2002 / HbVar: a relational database of human hemoglobin variants and thalassemia mutations at the globin gene server / Hum Mutat 19 : 225 ~ 233
Kawata R / 1988 / Hyperunstable hemoglobin Koriyama anti-Hb Gun Hill insertion of five residues in the beta chain / Hemoglobin 12 : 311 ~ 321
Natarajan K / 2010 / Disorders of hemoglobin structure: sickle cell anemia and related abnormalities, In Williams Hematology. 8th ed / McGraw-Hill
Patrinos GP / 2004 / Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies / Nucleic Acids R
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