지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 519 - 522 (4page)
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초록· 키워드
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High-resolution imaging techniques have increased the detection rate of adrenal incidentaloma. We developed a method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for detection of plasma free metanephrine (MN) and normetanephrine (NMN) and evaluated its analytical performance and clinical efficacy in differential diagnosis of adrenal incidentaloma. After solid-phase extraction, chromatographic isolation of the analytes and internal standard was achieved by column elution in the LC-MS/MS system. The analytes were detected in multiple-reaction monitoring mode by using positive electrospray ionization: MN, transition m/z 180.1→165.1; NMN, m/z 166.1→134.1. This method was validated for linearity, precision, accuracy, lower limits of quantification and detection, extraction recovery, and the matrix effect. Plasma concentrations of MN and NMN of 14 patients with pheochromocytoma were compared with those of 17 healthy volunteers, 10 patients with essential hypertension, and 60 patients with adrenal adenoma. The assay’s linear range was 0.04-50.0 and 0.08-100.0 nmol/L for MN and NMN, respectively. Assay imprecision was 1.86-7.50%. The accuracy ranged from -7.50% to 2.00%, and the mean recovery of MN and NMN was within the range 71.5-95.2%. Our LC-MS/MS method is rapid, accurate, and reliable and useful for differential diagnosis of adrenal incidentaloma.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Bravo EL / 1994 / Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma / Endocr Rev 15 : 356 ~ 368
Eisenhofer G / 2003 / Pheochromocytoma: rediscovery as a catecholamine-metabolizing tumor / Endocr Pathol 14 : 193 ~ 212
Eisenhofer G / 2008 / Current progress and future challenges in the biochemical diagnosis and treatment of pheochromocytomas and paragangliomas / Horm Metab Res 40 : 329 ~ 3
Grossman A / 2006 / Biochemical diagnosis and localization of pheochromocytoma: can we reach a consensus? / Ann N Y Acad Sci 1073 : 332 ~ 347
Lagerstedt SA / 2004 / Measurement of plasma free metanephrine and normetanephrine by liquid chromatography-tandem mass spectrometry for diagnosis of pheochromocytoma / Clin
Eisenhofer G / 2003 / Pheochromocytoma: rediscovery as a catecholamine-metabolizing tumor / Endocr Pathol 14 : 193 ~ 212
Eisenhofer G / 2008 / Current progress and future challenges in the biochemical diagnosis and treatment of pheochromocytomas and paragangliomas / Horm Metab Res 40 : 329 ~ 3
Grossman A / 2006 / Biochemical diagnosis and localization of pheochromocytoma: can we reach a consensus? / Ann N Y Acad Sci 1073 : 332 ~ 347
Lagerstedt SA / 2004 / Measurement of plasma free metanephrine and normetanephrine by liquid chromatography-tandem mass spectrometry for diagnosis of pheochromocytoma / Clin
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