지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 166 - 169 (4page)
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Patients with infantile ALL are fundamentally different from adult patients in that infants have a worse prognosis, which is attrib- uted to the increased relative incidence of MLL gene rearrange- ments [1, 2]. MLL is located on chromosome 11q23 and is a frequent target of chromosome translocations in hematopoietic malignancies. Patients with ALL and MLL rearrangements usu- ally have distinct characteristics, such as organomegaly, marked leukocytosis, and a high incidence of central nervous system leukemia [3, 4]. Most importantly, regardless of the age at pre- sentation, MLL rearrangement in ALL is associated with a poor response to therapy and a poor prognosis [5].
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참고문헌 (20)
참고문헌 신청
Ayton PM / 2001 / Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins / Oncogene 20 : 5695 ~ 5707
Blin N / 2008 / Mature B-cell lymphoblastic leukemia with MLL rearrangement: an uncommon and distinct subset of childhood acute leukemia / Leukemia 22 : 1056 ~ 1059
Dobson CL / 1999 / The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis / EMBO J 18 : 3564 ~ 3574
Frater JL / 2004 / Lymphoblastic leukemia with mature B-cell phenotype in infancy / J Pediatr Hematol Oncol 26 : 672 ~ 677
Hammami A / 1991 / Mature B-cell acute leukemia: a clinical, morphological, immunological, and cytogenetic study of nine cases / Hematol Pathol 5 : 109 ~ 118
Blin N / 2008 / Mature B-cell lymphoblastic leukemia with MLL rearrangement: an uncommon and distinct subset of childhood acute leukemia / Leukemia 22 : 1056 ~ 1059
Dobson CL / 1999 / The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis / EMBO J 18 : 3564 ~ 3574
Frater JL / 2004 / Lymphoblastic leukemia with mature B-cell phenotype in infancy / J Pediatr Hematol Oncol 26 : 672 ~ 677
Hammami A / 1991 / Mature B-cell acute leukemia: a clinical, morphological, immunological, and cytogenetic study of nine cases / Hematol Pathol 5 : 109 ~ 118
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