지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 887 - 892 (6page)
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초록· 키워드
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Central pontine myelinolysis is a rare neurologic disorder that is defined by demyelination of longitudinally descending tracts and transversly crossing fibers in the basis pontis. Frequently observed clinical manifestations of this disorder include sudden weakness, dysphagia, loss of consciouness and locked-in syndrome. However, there have been a few studies that reported a benign course of this disease, which include cerebellar signs, such as ataxia, intention tremor, and dysarthria. Here we report on a 53-year-old male with a history of liver cirrhosis who showed the cerebellar type of central pontine myelinolysis. The patient was diagnosed with central pontine myelinolysis based on clinical presentations and magnetic resonance imaging findings after a liver transplantation. Conventional magenetic resonance imaging (MRI) revealed the preservation of the corticospinal tract and abnormal pontocerebellar fibers. However, these findings were not sufficient to define the pathophysiology of our patient. Electrophysiologic analysis and diffusion tensor imaging (DTI) were performed to investigate cerebellar signs in this case. Delayed central motor conduction time (CMCT) to the tibialis anterior muscle with transcranial magnetic stimulation (TMS) was observed, which indicated demyelination of the corticospinal tract. Also, diffusion tensor imaging showed abnormal pontocerebellar fibers, which might have been caused by cerebellar dysfunction in our patient. A combination of TMS and DTI was also used to determine the pathophysiology of this disease.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Bassetti C / 1994 / Multimodal electrophysiological studies including motor evoked potentials in patients with locked-in syndrome: report of six patients / J Neurol Neurosurg
De Simone T / 2005 / Wallerian degeneration of the pontocerebellar fibers / Am J Neuroradiol 26 : 1062 ~ 1065
Garzon T / 2002 / Ataxic form of central pontine myelinolysis / Lancet Neurol 1 : 517 ~ 518
Kim J / 2005 / Decreased fractional anisotropy of middle cerebellar peduncle in crossed cerebellar diaschisis: diffusion-tensor imaging- positron-emission tomography correlat
Laubenberger J / 1996 / Central pontine myelinolysis: clinical presentation and radiologic findings / Eur Radiol 6 : 177 ~ 183
De Simone T / 2005 / Wallerian degeneration of the pontocerebellar fibers / Am J Neuroradiol 26 : 1062 ~ 1065
Garzon T / 2002 / Ataxic form of central pontine myelinolysis / Lancet Neurol 1 : 517 ~ 518
Kim J / 2005 / Decreased fractional anisotropy of middle cerebellar peduncle in crossed cerebellar diaschisis: diffusion-tensor imaging- positron-emission tomography correlat
Laubenberger J / 1996 / Central pontine myelinolysis: clinical presentation and radiologic findings / Eur Radiol 6 : 177 ~ 183
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