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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 786 - 792 (7page)
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초록· 키워드
오류제보하기
Objective To investigate the question of whether serum leptin levels might be associated with post-stroke depression.Methods We studied 130 patients who experienced a first episode of stroke of more than three months’ duration, without any previous history of depression or speech disorders. Data were collected regarding the patient demographics, depressive mood (Diagnostic and Statistical Manual of Mental Disorders 4th edition [DSM-IV] criteria and Beck Depression Inventory) and serum leptin levels measured by an enzyme-linked immunosorbent assay (ELISA). In addition, the Korean version of Modified Barthel Index (K-MBI) and Korean version of Mini-Mental State Examination (K-MMSE) were used to assess the subjects’ independence, in regard to the activities of daily living and cognition. A statistical analysis was performed to determine differences the serum leptin levels between patients with depression and those without depression, and to determine the difference in the MBI and K-MMSE scores between the groups separated according to the serum leptin levels.Results Higher serum leptin levels were observed in patients with depression, compared with those without depression (38.5 ng/mL [range, 25.1–59.2 ng/mL] vs. 8.2 ng/mL [range, 4.9–17.8 ng/mL]; p<0.01. The serum leptin level showed an association with depression (odds ratio, 1.21; 95% confidence interval, 1.01–1.45; p=0.021). The K-MMSE and K-MBI improvement scores were lower, with statistical significance, in the group with the highest leptin level (>30 mg/dL), compared to the other two groups.Conclusion High serum leptin levels are associated with depression after stroke, and patients with elevated serum leptin levels were disadvantaged in regard to functional and cognitive outcomes.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Altar CA. / 1999 / Neurotrophins and depression / Trends Pharmacol Sci 20 : 59 ~ 61
Antonijevic IA / 1998 / Elevated nocturnal profiles of serum leptin in patients with depression / J Psychiatr Res 32 : 403 ~ 410
Bouret SG. / 2010 / Neurodevelopmental actions of leptin / Brain Res 1350 : 2 ~ 9
Brown C / 2012 / Poststroke depression and functional independence: a conundrum / Acta Neurol Scand 126 : 45 ~ 51
Carvalho AF / 2014 / Adipokines as emerging depression biomarkers: a systematic review and meta-analysis / J Psychiatr Res 59 : 28 ~ 37
Antonijevic IA / 1998 / Elevated nocturnal profiles of serum leptin in patients with depression / J Psychiatr Res 32 : 403 ~ 410
Bouret SG. / 2010 / Neurodevelopmental actions of leptin / Brain Res 1350 : 2 ~ 9
Brown C / 2012 / Poststroke depression and functional independence: a conundrum / Acta Neurol Scand 126 : 45 ~ 51
Carvalho AF / 2014 / Adipokines as emerging depression biomarkers: a systematic review and meta-analysis / J Psychiatr Res 59 : 28 ~ 37
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