지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 839 - 847 (9page)
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초록· 키워드
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Objective To evaluate the pathophysiological mechanism of hemifacial spasm (HFS), we performed electrophysiological examinations, such as supraorbital nerve stimulation with orbicularis oris muscle recording and lateral spread tests, after suppressing the patient’s central nervous system by administering intravenous diazepam.Methods Six patients with HFS were recruited. Supraorbital nerve stimulation with orbicularis oris muscle recording and the lateral spread test were performed, followed by intravenous application of 10 mg diazepam to achieve facial motor neuron suppression. Subsequently, we repeated the two electrophysiological experiments mentioned above at 10 and 20 minutes after the patients had received the diazepam intravenously.Results Orbicularis oris muscle responses were observed in all patients after supraorbital nerve stimulation and lateral spread tests. After the diazepam injection, no orbicularis oris muscle response to supraorbital nerve stimulation was observed in one patient, and the latencies of this response were evident as a slowing tendency with time in the remaining five patients. However, the latencies of the orbicularis oris muscle responses were observed consistently in all patients in the lateral spread test.Conclusion Our results suggest that ectopic excitation/ephaptic transmission contributes to the pathophysiological mechanisms of HFS. This is because the latencies of the orbicularis oris muscle responses in the lateral spread test were observed consistently in the suppressed motor neuron in our patients.
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참고문헌 (26)
참고문헌 신청
Auger RG. / 1979 / Hemifacial spasm: clinical and electrophysiologic observations / Neurology 29 (9 Pt 1) : 1261 ~ 1272
Cossu G. / 1999 / Reflex excitability of facial motoneurons at onset of muscle reinnervation after facial nerve palsy / Muscle Nerve 22 : 614 ~ 620
Cruccu G. / 1991 / Nociceptive quality of the orbicularis oculi reflexes as evaluated by distinct opiate-and benzodiazepineinduced changes in man / Brain Res 556 : 209 ~ 217
Delwaide PJ. / 1983 / Central actions of
Eekhof JL. / 2000 / Blink reflexes and lateral spreading in patients with synkinesia after Bell’s palsy and in hemifacial spasm / Eur Neurol 43 : 141 ~ 146
Cossu G. / 1999 / Reflex excitability of facial motoneurons at onset of muscle reinnervation after facial nerve palsy / Muscle Nerve 22 : 614 ~ 620
Cruccu G. / 1991 / Nociceptive quality of the orbicularis oculi reflexes as evaluated by distinct opiate-and benzodiazepineinduced changes in man / Brain Res 556 : 209 ~ 217
Delwaide PJ. / 1983 / Central actions of
Eekhof JL. / 2000 / Blink reflexes and lateral spreading in patients with synkinesia after Bell’s palsy and in hemifacial spasm / Eur Neurol 43 : 141 ~ 146
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