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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 511 - 515 (5page)
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초록· 키워드
오류제보하기
Background: The syphilis diagnostic algorithms applied in different countries vary significantly depending on the local syphilis epidemiology and other considerations, including the expected workload, the need for automation in the laboratory and budget factors. This study was performed to investigate the efficacy of traditional and reverse syphilis diagnostic algorithms during general health checkups.
Methods: In total, 1,000 blood specimens were obtained from 908 men and 92 women during their regular health checkups. Traditional screening and reverse screening were applied to the same specimens using automatic rapid plasma regain (RPR) and Treponema pallidum latex agglutination (TPLA) tests, respectively. Specimens that were reverse algorithm (TPLA) reactive, were subjected to a second treponemal test performed by using the chemiluminescent microparticle immunoassay (CMIA).
Results: Of the 1,000 specimens tested, 68 (6.8%) were reactive by reverse screening (TPLA) compared with 11 (1.1%) by traditional screening (RPR). The traditional algorithm failed to detect 48 specimens [TPLA(+)/RPR(-)/CMIA(+)]. The median TPLA cutoff index (COI) was higher in CMIA-reactive cases than in CMIA-nonreactive cases (90.5 vs 12.5 U).
Conclusions: The reverse screening algorithm could detect the subjects with possible latent syphilis who were not detected by the traditional algorithm. Those individuals could be provided with opportunities for evaluating syphilis during their health checkups. The COI values of the initial TPLA test may be helpful in excluding false-positive TPLA test results in the reverse algorithm
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Binnicker MJ / 2012 / Direct comparison of the traditional and reverse syphilis screening algorithms in a population with a low prevalence of syphilis / J Clin Microbiol 50 :
Centers for Disease Control and Prevention / 2011 / Discordant results from reverse sequence syphilis screening-five laboratories, United States, 2006-2010 / MMWR Morb Morta
Greenblatt RM / 1998 / Genital ulceration as a risk factor for human immunodeficiency virus infection / AIDS 2 : 47 ~ 50
Loeffelholz MJ / 2012 / It is time to use treponema-specific antibody screening tests for diagnosis of syphilis / J Clin Microbiol 50 : 2 ~ 6
Mehta SD / 2006 / HIV seroconversion among public sexually transmitted disease clinic patients: analysis of risks to facilitate early identification / J Acquir Immune Defic S
Centers for Disease Control and Prevention / 2011 / Discordant results from reverse sequence syphilis screening-five laboratories, United States, 2006-2010 / MMWR Morb Morta
Greenblatt RM / 1998 / Genital ulceration as a risk factor for human immunodeficiency virus infection / AIDS 2 : 47 ~ 50
Loeffelholz MJ / 2012 / It is time to use treponema-specific antibody screening tests for diagnosis of syphilis / J Clin Microbiol 50 : 2 ~ 6
Mehta SD / 2006 / HIV seroconversion among public sexually transmitted disease clinic patients: analysis of risks to facilitate early identification / J Acquir Immune Defic S
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