지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제11권 제3호
- 발행연도
- 2013.1
- 수록면
- 158 - 164 (7page)
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초록· 키워드
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Objective: The demand for rapid and broad clinical toxicology screening methods to identify drugs of abuse and medicinal drugs is increasing steadily. Liquid chromatography-tandem mass spectrometry (LC-TMS) is increasingly used to screen for drugs of abuse and to identify a wide range of drugs and metabolites in clinical samples. We revised a high-throughput and rapid ultra-performance (UP) LC-TMS method for simultaneous screening of 177 of the most prevalent medicinal drugs and drugs of abuse in urine and validated the quality of performance using system suitability mixture (SSM) and quality control (QC) materials.
Methods: We assessed the limits of detection (LOD) using high concentrations of the test substances. The method was applied to 473 urine samples obtained from patients intoxicated with drugs who visited the emergency center.
Results: The retention time, peak area, and total ion chromatogram of the SSM and QC materials were within the acceptance criteria of the pre-defined acceptance interval. The LODs were ＜62 ng/ml for 12 commonly encountered drugs. In total, 418patients (88.4%) tested positive for one or more medicinal drugs or drugs of abuse. Twenty-eight drugs were detected over ten times; the most commonly detected were zolpidem, ephedrine, paracetamol, and chlorpheniramine.
Conclusion: The UPLC-TMS method provided excellent performance for simultaneous screening of a large number of the drugs of abuse in urine samples. We conclude that this robust technique is useful for screening for a large number of drugs and for rapid screening of the most commonly encountered substances in emergency cases.
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참고문헌 (14)
참고문헌 신청
Adamowicz P / 2010 / Simultaneous screening for and determination of 128 date-rape drugs in urine by gas chromatography- electron ionization-mass spectrometry / Forensic Sci
Eichhorst JC / 2009 / Drugs of abuse testing by tandem mass spectrometry: a rapid, simple method to replace immunoassays / Clin Biochem 42 : 1531 ~ 1542
Gunnar T / 2004 / Validated semiquantitative/quantitative screening of 51 drugs in whole blood as silylated derivatives by gas chromatography-selected ion monitoring mass spe
Lillsunde P / 1996 / Comprehensive drug screening in blood for detecting abused drugs or drugs potentially hazardous for traffic safety / Forensic Sci Int 77 : 191 ~ 210
Lynch KL / 2010 / Performance evaluation of three liquid chromatography mass spectrometry methods for broad spectrum drug screening / Clin Chim Acta 411 : 1474 ~ 1481
Eichhorst JC / 2009 / Drugs of abuse testing by tandem mass spectrometry: a rapid, simple method to replace immunoassays / Clin Biochem 42 : 1531 ~ 1542
Gunnar T / 2004 / Validated semiquantitative/quantitative screening of 51 drugs in whole blood as silylated derivatives by gas chromatography-selected ion monitoring mass spe
Lillsunde P / 1996 / Comprehensive drug screening in blood for detecting abused drugs or drugs potentially hazardous for traffic safety / Forensic Sci Int 77 : 191 ~ 210
Lynch KL / 2010 / Performance evaluation of three liquid chromatography mass spectrometry methods for broad spectrum drug screening / Clin Chim Acta 411 : 1474 ~ 1481
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