지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제4호
- 발행연도
- 2017.1
- 수록면
- 361 - 368 (8page)
이용수
초록· 키워드
오류제보하기
Objective: Several studies have suggested the efficacy of bupropion and escitalopram on reducing the excessive internet game play. We hypothesized that both bupropion and escitalopram would be effective on reducing the severity of depressive symptoms and internet gaming disorder (IGD) symptoms in patients with both major depressive disorder and IGD. However, the changes in brain connectivity between the default mode network (DMN) and the salience network were different between bupropion and escitalopram due to their different pharmacodynamics. Methods: This study was designed as a 12-week double blind prospective trial. Thirty patients were recruited for this research (15 bupropion group+15 escitalopram group). To assess the differential functional connectivity (FC) between the hubs of the DMN and the salience network, we selected 12 regions from the automated anatomical labeling in PickAtals software. Results: After drug treatment, the depressive symptoms and IGD symptoms in both groups were improved. Impulsivity and attentional symptoms in the bupropion group were significantly decreased, compared to the escitalopram group. After treatment, FC within only the DMN in escitalopram decreased while FC between DMN and salience network in bupropion group decreased. Bupropion was associated with significantly decreased FC within the salience network and between the salience network and the DMN, compared to escitalopram. Conclusion: Bupropion showed greater effects than escitalopram on reducing impulsivity and attentional symptoms. Decreased brain connectivity between the salience network and the DMN appears to be associated with improved excessive IGD symptoms and impulsivity in MDD patients with IGD.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Aboujaoude E / 2006 / Potential markers for problematic internet use: a telephone survey of 2,513 adults / CNS Spectr 11 : 750 ~ 755
Conners CK / 1996 / Bupropion hydrochloride in attention deficit disorder with hyperactivity / J Am Acad Child Adolesc Psychiatry 35 : 1314 ~ 1321
Dell'Osso B / 2008 / Escitalopram in the treatment of impulsivecompulsive internet usage disorder : an open-label trial followed by a double-blind discontinuation phase / J C
Goulden N / 2014 / The salience network is responsible for switching between the default mode network and the central executive network : replication from DCM / Neuroimage 9
Ha JH / 2006 / Psychiatric comorbidity assessed in Korean children and adolescents who screen p
Conners CK / 1996 / Bupropion hydrochloride in attention deficit disorder with hyperactivity / J Am Acad Child Adolesc Psychiatry 35 : 1314 ~ 1321
Dell'Osso B / 2008 / Escitalopram in the treatment of impulsivecompulsive internet usage disorder : an open-label trial followed by a double-blind discontinuation phase / J C
Goulden N / 2014 / The salience network is responsible for switching between the default mode network and the central executive network : replication from DCM / Neuroimage 9
Ha JH / 2006 / Psychiatric comorbidity assessed in Korean children and adolescents who screen p
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