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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제1호
- 발행연도
- 2018.1
- 수록면
- 103 - 108 (6page)
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초록· 키워드
오류제보하기
Objective: Evidence has suggested that immune imbalance is involved with bipolar disorder (BD); however, its precise mechanism is poorly understood. This study investigated whether biochemical changes in the serum from BD patients could modulate the phenotype of cultured macrophages. Methods: Eighteen subjects with BD and five healthy individuals were included in this study. The human monocyte cell line U-937 was activated with phorbol 12-myristate 13-acetate (PMA) and polarization was induced with RPMI-1640 media supplemented with 10% serum from each patient for 24 hours. Gene expression of selected M1 and M2 markers was assessed by quantitative PCR. Results: Macrophages exposed to serum of manic and depressive BD patients displayed an increase of interleukin-1 (6.40±3.47 and 9.04±5.84 vs. 0.23±0.11; p＜0.05) and tumor necrosis factor- (2.23±0.91 and 2.03±0.45 vs. 0.62±0.24; p=0.002 and p=0.004, respectively) compared to euthymic group (there was no difference between euthymic and controls). In parallel, U-937 macrophages treated with serum of patients in acute episode displayed a down-regulation of CXCL9 (0.29±0.20 vs. 1.86±1.61; p=0.006) and CXCL10 expression (0.36±0.15 and 0.86±0.24 vs. 1.83±0.88; p＜0.000 and p=0.04) compared to the euthymia group. Conclusion: Our results are consistent with previous studies showing that changes in peripheral blood markers could modulate M1/M2 polarization in BD. The evidence of macrophages as source of inflammatory cytokines might be helpful to unravel how the mononuclear phagocyte system is involved in the etiology of BD.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Bai YM / 2015 / Comparison of pro-inflammatory cytokines among patients with bipolar disorder and unipolar depression and normal controls / Bipolar Disord 17:269~277
Dargel AA / 2015 / C-reactive protein alterations in bipolar disorder: a meta-analysis / J Clin Psychiatry 76:142~150
do Prado CH / 2013 / Reduced regulatory T cells are associated with higher levels of Th1/TH17 cytokines and activated MAPK in type 1 bipolar disorder / Psychoneuroendocrinology 38:667~676
Fiedorowicz JG / 2015 / Peripheral inflammation during abnormal mood states in bipolar I disorder / J Affect Disord 187:172~178
Kauer-Sant'Anna M / 2009 / Brain-derived neurotrophic factor and inflammatory markers in patients with early-vs. late-stage bipolar disorder / Int J Neuropsychopharmacol 12:447~458
Dargel AA / 2015 / C-reactive protein alterations in bipolar disorder: a meta-analysis / J Clin Psychiatry 76:142~150
do Prado CH / 2013 / Reduced regulatory T cells are associated with higher levels of Th1/TH17 cytokines and activated MAPK in type 1 bipolar disorder / Psychoneuroendocrinology 38:667~676
Fiedorowicz JG / 2015 / Peripheral inflammation during abnormal mood states in bipolar I disorder / J Affect Disord 187:172~178
Kauer-Sant'Anna M / 2009 / Brain-derived neurotrophic factor and inflammatory markers in patients with early-vs. late-stage bipolar disorder / Int J Neuropsychopharmacol 12:447~458
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