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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제13권 제1호
- 발행연도
- 2015.1
- 수록면
- 83 - 93 (11page)
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초록· 키워드
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Objective: The present study sought to analyze the influence of Levetiracetam (LEV) in cognitive performance by identifying the changes produced by LEV in reaction time, in neuropsychological assessment of attention and memory and in absolute theta power in frontal activity.
Methods: Twelve healthy subjects (5 men and 7 women; mean age, 30.08 years, standard deviation, 4.71) were recruited for this study. The neuropsychological tests: Trail Making Test (A and B), Digit Span (direct and indirect numerical orders/working memory); Stroop test (inhibitory control of attention); Tower of London (planning and decision-making) and a quantitative electroencephalography were applied in 2 different days after and before the participants ingested the capsule of placebo or 500 mg LEV.
Results: A two-way-ANOVA was implemented to observe the interaction between conditions (placebo or LEV 500 mg) and moments (pre- and post-ingestion of LEV or placebo). The data were analyzed by the SPSS statistical package (p＜0.05). For the neuropsychological parameter, the Trail Making Test (A) was the only test that showed significant difference for condition in the task execution time (p=0.026). Regarding the reaction time in the behavioral parameter, an interaction between both factors (p=0.034) was identified through a two-way-ANOVA (condition versus moment). Electrophysiological measures showed a significant interaction for electrodes: F7, F3, and FZ.
Conclusion: The findings showed that LEV promotes an important cognitive enhancement in the executive functions.
목차
등록된 정보가 없습니다.
참고문헌 (80)
참고문헌 신청
박성파 / 2009 / Increased EEG Current-Source Density in the High Beta Frequency Band Induced by Levetiracetam Adjunctive Therapy in Refractory Partial Epilepsy / Journal of Clinical Neurology 5(4):178~185
Smith ME. / 1999 / Neurophysiological indices of strategy development and skill acquisition / Brain Res Cogn Brain Res 7:389~404
Sanchez PE. / 2012 / Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model / Proc Natl Acad Sci U S A 109:E2895~E2903
Cho JR. / 2012 / Effect of levetiracetam monotherapy on background EEG activity and cognition in drug-naïve epilepsy patients / Clin Neurophysiol 123:883~891
Putman P. / 2014 / EEG theta/beta ratio as a potential biomarker for attentional control and resilience against deleterious effects of stress on attention / Cogn Affect Behav Neurosci 14:782~791
Smith ME. / 1999 / Neurophysiological indices of strategy development and skill acquisition / Brain Res Cogn Brain Res 7:389~404
Sanchez PE. / 2012 / Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model / Proc Natl Acad Sci U S A 109:E2895~E2903
Cho JR. / 2012 / Effect of levetiracetam monotherapy on background EEG activity and cognition in drug-naïve epilepsy patients / Clin Neurophysiol 123:883~891
Putman P. / 2014 / EEG theta/beta ratio as a potential biomarker for attentional control and resilience against deleterious effects of stress on attention / Cogn Affect Behav Neurosci 14:782~791
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