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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제14권 제1호
- 발행연도
- 2016.1
- 수록면
- 101 - 103 (3page)
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초록· 키워드
오류제보하기
Lithium is the first line treatment for maintenance treatment of bipolar disorder. Among the long term adverse effects, weight gain is likely to affect a subset of patients. There is no specific guideline for the treatment of lithium-induced weight gain. We report a young male with bipolar disorder who had significant weight gain with lithium (25 kg), which responded to metformin treatment at 500 mg twice daily. The proposed mechanism of weight lowering effect of metformin includes changes in hypothalamic physiology, including leptin and insulin sensitivity, as well as circadian rhythm changes affecting food intake, regulation of fat oxidation and storage in liver, skeletal muscle, and adipose tissue.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Coryell W / 2009 / Maintenance treatment in bipolar disorder: a reassessment of lithium as the first choice / Bipolar Disord 11(Suppl 2):77~83
McKnight RF / 2012 / Lithium toxicity profile: a systematic review and meta-analysis / Lancet 379:721~728
Garland EJ / 1988 / Weight gain with antidepressants and lithium / J Clin Psychopharmacol 8:323~330
Baptista T / 1995 / Lithium and body weight gain / Pharmacopsychiatry 28:35~44
Torrent C / 2008 / Weight gain in bipolar disorder: pharmacological treatment as a contributing factor / Acta Psychiatr Scand 118:4~18
McKnight RF / 2012 / Lithium toxicity profile: a systematic review and meta-analysis / Lancet 379:721~728
Garland EJ / 1988 / Weight gain with antidepressants and lithium / J Clin Psychopharmacol 8:323~330
Baptista T / 1995 / Lithium and body weight gain / Pharmacopsychiatry 28:35~44
Torrent C / 2008 / Weight gain in bipolar disorder: pharmacological treatment as a contributing factor / Acta Psychiatr Scand 118:4~18
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