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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한치과보철학회 대한치과보철학회지 대한치과보철학회지 제46권 제3호
발행연도
2008.1
수록면
307 - 319 (13page)

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STATEMENT OF PROBLEM: It is known that an anodic oxidation technique, one of the methods for the implant surface treatment, remarkably increased surface area, enhanced wettability and accelerated the initial bone healing. Purpose: This study was performed to evaluate the wettability of anodized titanium surface which has a nanotubular structure, to assess osseointegration after the placement of implant with nano-size tubes on tibia of rats and to analyze quantitatively transferable rhBMP-2 on each surface. MATERIAL AND METHOD: Four different kinds of surface-treated titanium discs (polished (machined surface) group, micro (blasting surface) group, nano (anodizedmachined surface) group, and nano-micro (anodized-blasting surface) group) were fabricated (n=10). Three different media were chosen to measure the surface contact angles; distilled water, plasma and rhBMP-2 solution. After a single drop (0.025 ㎖) of solution, the picture was taken with the image camera, and contact angle was measured by using image analysis system. For the test of osseointegration, 2 kinds of anodized surface (anodized-machined surface, anodized-blasting surface) implants having 2.0 ㎜ in diameter and 5.0 ㎜ in length inserted into the tibia of Wistar rats. After 3 weeks, tibia were harvested and the specimens were stained with hematoxylin and eosin for histological analysis. To test the possibility of drug delivery, after soaking sample groups in the concentration of 250 ng/㎖ of rhBMP-2 for 48 hours, the excess solution of rhBMP-2 were removed. After that, they were lyophilized for 24 hours, and then the rhBMP-2 on the surface of titanium was resolved for 72 hours in PBS. All the extracted solution was analyzed by ELISA. One-way analysis of variance (ANOVA) was performed on the data. RESULTS: The wettability is improved by anodic oxidation. The best wettability was shown on the nano-micro group, and it was followed by nano group, micro group, and polished group. In the histological findings, all implants showed good healing and the new bone formation were observed along the implant surface. After 3 days, nano-micro group delivered the most amount of rhBMP-2, followed by nano group, micro group, and polished group. CONCLUSION: It indicated that anodic oxidation on blasting surface produce functionally graded nano-micro porous structure and enhance hydrophilicity of the surface and osseointegration. The findings suggest that the nano-micro porous structure could be a useful carrier of osteogenic molecules like rhBMP-2.
#Wettability #Drug delivery #Nano-micro porous #Titanium surface

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참고문헌 (28)

참고문헌 신청
Clokie CM / 1995 / Morphologic and radioautographic studies of bone formation in relation to titanium implants using the rat tibia as a model / Int J Oral Maxillofac Implants 10:155~165 google schola Yanagisawa I / 1989 / Effects o“f wettability” of biomaterials on culture cells / J Oral Implantol 15:168~177 google schola Sachse A / 2005 / Osteointegration of hydroxyapatite-titanium implants coated with nonglycosylated recombinant human bone morphogenetic protein-2 (BMP-2) in aged sheep / Bone 37:699~710 google schola Liu Y / 2005 / BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model / Bone 36:745~757 google schola Albrektsson T / 1988 / Osseointegrated oral implants. A Swedish multicenter study of 8139 consecutively inserted Nobelpharma implants / J Periodontal 59 : 287 ~ 296 google schola

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