지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치과보철학회 The Journal of Advanced of Prosthodontics The Journal of Advanced of Prosthodontics 제2권 제1호
- 발행연도
- 2010.1
- 수록면
- 7 - 13 (7page)
이용수
초록· 키워드
오류제보하기
PURPOSE. Although most researchers agree that platelet-rich plasma (PRP) is a good source of autogenous growth factors, its effect on bone regeneration is still controversial. The purpose of this study was to evaluate whether increasing angiogenic factors in the human PRP to enhance new bone formation through rapid angiogenesis. MATERIAL AND METHODS. In vitro, the human platelets were activated with application of shear stress, 20 g/ml collagen, 2 mM CaCl2 and 10U thrombin/1 x 109 platelets. Level of vascular endothelial growth factor (VEGF) and platelet microparticle (PMP) in the activated platelets were checked. In the animal study, human angiogenic factors-enriched PRP was tested in 28 athymic rat’s cranial critical bone defects with -TCP. Angiogenesis and osteogenesis were evaluated by laser Doppler perfusion imaging, histology, dual energy X-ray densinometry, and micro-computed tomography. RESULTS. In vitro, this human angiogenic factors-enriched PRP resulted in better cellular proliferation and osteogenic differentiation. In vivo, increasing angiogenic potential of the PRP showed significantly higher blood perfusion around the defect and enhanced new bone formation around acellular bone graft material. CONCLUSION. Angiogenic factor-enriched PRP leads to faster and more extensive new bone formation in the critical size bone defect. The results implicate that rapid angiogenesis in the initial healing period by PRP could be supposed as a way to overcome short term effect of the rapid angiogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Benjamin LE / 1999 / Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal / J Clin Invest 103 : 159
Borrelli V / 2001 / Bimodal concentration-dependent effect of thrombin on endothelial cell proliferation and growth factor release in culture / J Surg Res 100 : 154 ~ 160
Butterfield KJ / 2005 / Effect of platelet-rich plasma with autogenous bone graft for maxillary sinus augmentation in a rabbit model / J Oral Maxillofac Surg 63 : 370 ~ 376
Chow KM / 2000 / Vascular endothelial growth pattern of endochondral bone graft in the presence of demineralized intramembranous bone matrix--quantitative analysis / Cleft Pa
Fu¨rst G / 2003 / Sinus grafting with autogenous plateletrich plasma and bovine hydroxyapatite.A histomorphometric study in minipigs / Clin Oral Implants Res 14 : 500 ~ 508
Borrelli V / 2001 / Bimodal concentration-dependent effect of thrombin on endothelial cell proliferation and growth factor release in culture / J Surg Res 100 : 154 ~ 160
Butterfield KJ / 2005 / Effect of platelet-rich plasma with autogenous bone graft for maxillary sinus augmentation in a rabbit model / J Oral Maxillofac Surg 63 : 370 ~ 376
Chow KM / 2000 / Vascular endothelial growth pattern of endochondral bone graft in the presence of demineralized intramembranous bone matrix--quantitative analysis / Cleft Pa
Fu¨rst G / 2003 / Sinus grafting with autogenous plateletrich plasma and bovine hydroxyapatite.A histomorphometric study in minipigs / Clin Oral Implants Res 14 : 500 ~ 508
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
치과영역에서의 PRP의 유용성
Oral Biology Research
2011 .01
-
Platelet-Rich Plasma: Quantitative Assessment of Growth Factor Levels and Comparative Analysis of Activated and Inactivated Groups
Archives of plastic surgery : APS
2013 .01
-
Case Report for Platelet rich plasma (PRP) in 2 Dogs
WITH CAP(COMPANION ANIMAL PRACTICE)
2018 .04
-
가토 상악동 거상술 후 Bovine Bone (Bio-Oss�)과 함께 이식된 혈소판풍부혈장과 혈소판결핍혈장의 골치유능 비교
대한구강악안면외과학회지
2010 .01
-
Why I am not doing PRP
대한견주관절의학회 학술대회논문집
2014 .03
-
비글견 경골에서 임플란트 식립 시 혈소판 농축 혈장이 골형성에 미치는 영향
대한구강악안면외과학회지
2010 .01
-
슬관절 부위에 대한 혈소판 풍부 혈장(Platelet-Rich Plasma) 치료 : 국내 현황, 임상 결과 고찰 및 법적 상황 : 2차 출판
대한정형외과학회지
2012 .10
-
Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study
Annals of Dermatology
2016 .01
-
양성 골 종양의 소파술 후 실시한 동종골 이식에서 혈소판 풍부 혈장 투여의 효과
대한골관절종양학회지
2010 .01
-
Current clinical applications of platelet-rich plasma in various gynecological disorders: An appraisal of theory and practice
Clinical and experimental reproductive medicine : CERM
2018 .01
-
Prospective Clinical Research of the Efficacy of Platelet-rich Plasma in the Outpatient-based Treatment of Rotator Cuff Tendinopathy
대한견주관절의학회지
2019 .06
-
Platelet-Rich Plasma Therapy for Knee Joint Problems: Review of the Literature, Current Practice and Legal Perspectives in Korea
Knee Surgery and Related Research
2012 .01
-
Does Platelet-rich Plasma Augmentation Following Hip Arthroscopy Improve Outcomes: A Systematic Review
Hip and Pelvis
2020 .01
-
Platelet-rich Plasma in Arthroscopic Rotator Cuff Repair
대한견주관절의학회지
2015 .06
-
Effect of Platelet-rich Plasma (PRP) on Regeneration of Rat Sciatic Nerve in a Silicone Chamber
대한성형외과학회지
2010 .01
-
Effects of Autologous Platelet-Rich Plasma on Regeneration of Damaged Endometrium in Female Rats
Yonsei Medical Journal
2017 .01
-
The Early Histological Effects of Intravesical Instillation of Platelet- Rich Plasma in Cystitis Models
International Neurourology Journal
2016 .01
-
Acceleration of Wound Healing Using Adipose-derived Stem Cell Therapy with Platelet Concentrates: Plateletrich Plasma (PRP) vs. Platelet-rich Fibrin (PRF)
대한성형외과학회지
2011 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0