지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제6권 제2호
- 발행연도
- 2008.1
- 수록면
- 65 - 70 (6page)
이용수
초록· 키워드
오류제보하기
Objective：Maternal social separation (MSS), a crucial early life experience, plays an essential role in the development of the nervous system. In our previous study, we demonstrated that the volume of the dentate gyrus decreases among rats experiencing MSS. Furthermore, chronic stress has been assumed to alter synaptic structures within the hippocampus. Therefore, we assessed the effects of MSS on neuronal morphology in the hippocampus and cerebral cortex.
Methods：Golgi histochemistry and calretinin immunohistochemistry were used to evaluate the structure of neurons from the hippocampus and cerebral cortex in control and MSS rats.
Results：Three weeks of maternal social separation was associated with morphological alteration of the apical dendrites of CA3 pyramidal neurons. Furthermore, calretinin-positive dentate pyramidal basket cells, GABAergic interneurons, significantly decreased in MSS rats. However, no morphological alterations of pyramidal neurons and interneurons in the cerebral cortex were observed. In addition, spine density in the terminal dendritic branches did not differ between control and MSS rats.
Conclusion：These findings demonstrate that maternal social separation is associated with changes in neuronal architecture, and with biological features that might underlie behavioral and learning impairments.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Abraham IM / 2000 / Postnatal handling alters the activation of stress-related neuronal circuitries / Eur J Neurosci 12 : 3003 ~ 3014
Amaral DG / 1995 / Hippocampal formation. In: Paxinos G, editor. The rat nervous system. 2nd ed / Academic Press : 443 ~ 494
Avishai-Eliner S / 2002 / Stressed out? Or in utero / Trends Neurosci 25 : 518 ~ 524
Bredy TW / 2003 / Partial reversal of the effect of maternal care on cognitive function through environmental enrichment / Neuroscience 118 : 571 ~ 576
Bremner D / 2001 / Stress and development: behavioral and biological consequences / Dev Psychopath 13 : 473 ~ 489
Amaral DG / 1995 / Hippocampal formation. In: Paxinos G, editor. The rat nervous system. 2nd ed / Academic Press : 443 ~ 494
Avishai-Eliner S / 2002 / Stressed out? Or in utero / Trends Neurosci 25 : 518 ~ 524
Bredy TW / 2003 / Partial reversal of the effect of maternal care on cognitive function through environmental enrichment / Neuroscience 118 : 571 ~ 576
Bremner D / 2001 / Stress and development: behavioral and biological consequences / Dev Psychopath 13 : 473 ~ 489
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