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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제39권 제3호
- 발행연도
- 2009.1
- 수록면
- 359 - 365 (7page)
이용수
초록· 키워드
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Purpose: The purpose of this study was to investigate the ability of Mineral trioxide aggregate(MTA) to support osteoclastic
differentiation from fetal rat calvarial cell.
Methods: In this study, response of IL-6, RANKL, and OPG in fetal rat calvarial cells stimulated with IL-1β on MTA
was evaluated by ELISA and RT-PCR.
Results: The results were as follows; there was no significant difference between glass and MTA at 5days. In ELISA analysis,
Glass group and MTA group showed similar IL-6 expression, Glass+IL-1β group and MTA+IL-1β group showed similar
IL-6 expression. In RT-PCR analysis, Glass group and MTA group showed similar IL-6, RANKL, OPG mRNA expression,
MTA+IL-1β group and Glass+IL-1β group showed 3 fold increase of IL-6 and RNAKL mRNA expression when
compared with MTA group. All groups showed similar OPG mRNA expression.
Conclusions: MTA does not suppress cell proliferation and increase the proinflammatory cytokine that induce
osteoclastogenesis. Thus, MTA is biocompatible material that could be used in various clinical conditions.
(J Korean Acad Periodontol 2009;39:359-365)
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참고문헌 (22)
참고문헌 신청
Barrieshi-Nusair K / 2006 / A prospective clinical study of mineral trioxide aggregate for partial pulpotomy in cariously exposed permanent teeth / J Endod 32 : 731 ~ 735
Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423 : 337 ~ 342
Cochran DL / 2008 / Inflammation and bone loss in periodontal disease / J Periodontol 79 : 1569 ~ 1576
Cory AH / 1991 / Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture / Cancer Commun 3 : 207 ~ 212
Dalrymple SA / 1996 / Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection / Infect Immun 64 : 3231 ~ 3235
Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423 : 337 ~ 342
Cochran DL / 2008 / Inflammation and bone loss in periodontal disease / J Periodontol 79 : 1569 ~ 1576
Cory AH / 1991 / Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture / Cancer Commun 3 : 207 ~ 212
Dalrymple SA / 1996 / Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection / Infect Immun 64 : 3231 ~ 3235
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