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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제43권 제3호
- 발행연도
- 2013.1
- 수록면
- 121 - 129 (9page)
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초록· 키워드
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Purpose: The present study has two aims; firstly, it attempts to verify the presence of oxidative stress by estimating the reactive oxygen species (ROS) levels in periodontal pockets ≥ 5 mm as compared to controls. The second aim is to evaluate the effect of lycopene as a locally delivered antioxidant gel on periodontal health and on the gingival crevicular fluid (GCF) levels of 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative injury.
Methods: Thirty-one subjects participated in this study. In the pretreatment phase, the ROS levels in pockets ≥ 5 mm were measured by flow cytometry. Three sites in each subject were randomly assigned into each of the following experimental groups:sham group, only scaling and root planing (SRP) was done; placebo group, local delivery of placebo gel after SRP; and lycopene group, local delivery of lycopene gel after SRP. Clinical parameters included recording site-specific measures of GCF 8-OHdG,plaque, gingivitis, probing depth, and clinical attachment level.
Results: The gel, when delivered to the sites with oxidative stress, was effective in increasing clinical attachment and in reducing gingival inflammation, probing depth, and 8-OHdG levels as compared to the placebo and sham sites.
Conclusions: From this trial conducted over a period of 6 months, it was found that locally delivered lycopene seems to be effective in reducing the measures of oxidative stress and periodontal disease.
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참고문헌 (24)
참고문헌 신청
Bagaitkar J / 2009 / Tobacco-induced alterations to Porphyromonas gingivalis-host interactions / Environ Microbiol 11 : 1242 ~ 1253
Battino M / 1999 / Oxidative injury and inflammatory periodontal diseases : the challenge of anti-oxidants to free radicals and reactive oxygen species / Crit Rev Oral Biol M
Borges I Jr / 2007 / Proinflammatory and oxidative stress markers in patients with periodontal disease / Mediators Inflamm 2007 : 45794 ~
Chandra RV / 2007 / Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo-controlled clinical trial / Oral Health Prev Dent 5 : 327 ~ 336
Chandra RV / 2012 / Efficacy of lycopene as a locally delivered gel in the treatment of chronic periodontitis : smokers vs nonsmokers / Quintessence Int 43 : 401 ~ 411
Battino M / 1999 / Oxidative injury and inflammatory periodontal diseases : the challenge of anti-oxidants to free radicals and reactive oxygen species / Crit Rev Oral Biol M
Borges I Jr / 2007 / Proinflammatory and oxidative stress markers in patients with periodontal disease / Mediators Inflamm 2007 : 45794 ~
Chandra RV / 2007 / Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo-controlled clinical trial / Oral Health Prev Dent 5 : 327 ~ 336
Chandra RV / 2012 / Efficacy of lycopene as a locally delivered gel in the treatment of chronic periodontitis : smokers vs nonsmokers / Quintessence Int 43 : 401 ~ 411
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