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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective: The purpose of this study is to report the case of a patient with recurring non-small cell lung carcinoma (NSCLC) taking Samchilchoongcho-Jung with Afatinib.
Methods: An NSCLC patient diagnosed with multiple bone and pulmonary metastasis was taking Afatinib (20 mg/day) and suffering from stomatitis caused by the Afatinib. The patient was treated with Samchilchoongcho-Jung (1,500 mg/ day) for 3 months. The tumor size was measured with computed tomography, and laboratory findings, including tumor markers (CEA, Cyfra 21-1), were also followed up. Stomatitis was measured by a numeric rating scale, and adverse events were evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 4.0.
Results: After combined treatment, stable disease was shown on computed tomography. The tumor marker levels of CEA and Cyfra 21-1 were decreased, and the stomatitis significantly improved. NCI-CTCAE 4.0 showed no adverse events.
Conclusion: This case study suggests that Samchilchoongcho-Jung may have a synergic effect, in conjunction with Afatinib, on the treatment of patients with recurring NSCLC.
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참고문헌 (21)
참고문헌 신청
Boolell V / 2015 / The Evolution of Therapies in Non-Small Cell Lung Cancer / Cancers(Basel) 7 (3) : 1815 ~ 1846
Chang SH / 2015 / Letter to Editor : Gamchosasim-tang, Sawi-tang and Giotrif Combination Therapy for Metastatic Non-Small-Cell Lung Adenocarcinoma ;A Regression Case / J of
Chou PY / 2011 / Trilinolein inhibits proliferation of human non-small cell lung carcinoma A549 through the modulation of PI3K/Akt pathway / Am J Chin Med 39 (4) : 803
Eisenhauer EA / 2009 / New response evaluation criteria in solid tumours: Revised RECIST guideline(version 1.1) / Eur J Cancer 45 (2) : 228 ~ 247
Kang HJ / 2016 / Inhibitory effects of HangAmDan-B1(HAD-B1) on A549 lung cancer cell proliferation and tumor growth in a xenograft model / Academia Journal of Scientific Res
Chang SH / 2015 / Letter to Editor : Gamchosasim-tang, Sawi-tang and Giotrif Combination Therapy for Metastatic Non-Small-Cell Lung Adenocarcinoma ;A Regression Case / J of
Chou PY / 2011 / Trilinolein inhibits proliferation of human non-small cell lung carcinoma A549 through the modulation of PI3K/Akt pathway / Am J Chin Med 39 (4) : 803
Eisenhauer EA / 2009 / New response evaluation criteria in solid tumours: Revised RECIST guideline(version 1.1) / Eur J Cancer 45 (2) : 228 ~ 247
Kang HJ / 2016 / Inhibitory effects of HangAmDan-B1(HAD-B1) on A549 lung cancer cell proliferation and tumor growth in a xenograft model / Academia Journal of Scientific Res
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