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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
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대한한방내과학회 대한한방내과학회지 대한한방내과학회지 제31권 제2호
발행연도
2010.1
수록면
314 - 330 (17page)

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Objective : This study was performed to investigate the anti-fibrogenic effect and changes of inflammation-related genes by YBR I and YBR Ⅱ (YBR I: Arteisiae Capillaris Herba, Atractylodis Rhizoma Alba, Hoelen/ YBR Ⅱ: YBR I +Sanguisorbae Radix, Biotae Cacumen, Cirsii Japonici Herba) on HSC(hepatic stellate cells)-T6 and TAA-induced rat liver tissue. Materials and Methods : HSC-T6 were treated with various concentrations of distilled-water extract YBR I and YBR Ⅱ extract for 24, 48 and 72 hours. After the treatment, cell viability, proliferation, procollagen levels and IL-6 levels were measured by using MTT Assay, BrdU Assay, Procollagen Type 1 C-peptide EIA kit, and Murine IL-6 ELISA Development kit. Rat liver fibrosis was induced by intraperitoneal TAA injection of 150mg/kg 3 times a week for 6 weeks. After the treatment, body weight, liver & spleen weights, liver function test, complete blood cell count and change of portal pressure were studied. In addition, gene expressions of ASMA, IL-6, MMP-2, TIMP-1 and TIMP-2, all of which are known to be associated with liver fibrosis, were analyzed by using Real-Time PCR. After YBR I and YBR Ⅱtreatment, percentages of collagen in TAA-induced rat liver tissue were measured. Results : The viability and proliferation of the HSC-T6 decreased as the concentration increased. The production of procollagen decreased as the concentration increased. The production of IL-6 was little influenced by YBR I and YBR Ⅱ. There was no difference in rat body weight between the TAA-only group and the YBR groups. Compared with rat liver weight of TAA-only group, that of the YBR groups increased. In the YBR I group, the serum level of AST elevated by TAA injection significantly decreased and in the YBR I and Ⅱ group, the serum level of ALP and ALT elevated by TAA injection decreased. In the YBR I group, white blood cell count elevated by TAA injection decreased but platelets increased. In the YBR I group, the portal pressure elevated by TAA injection significantly decreased. Decreases in the gene expression of ASMA and MMP-2 were observed in the YBR I group. The gene expression of IL-6 was little influenced by YBR I and YBR Ⅱ-treated groups. In the histological finding, TAA injections caused severe fibrosis, but YBR I and YBR Ⅱ treatment significantly reduced the amounts of hepatic collagens. Conclusions : These results suggest that YBR I and Ⅱ have inhibitory effects on the hepatic fibrogenesis.
#Arteisiae Capillaris Herba #TAA #Hepatic Stellate Cell

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참고문헌 (32)

참고문헌 신청
Friedman SL / 1993 / The cellular basis of hepatic fibrosis / N Engl J Med 25 : 1828 ~ 1835 google schola Friedman SL / 2003 / Liver fibrosis-from bench to beside / J Hepatol. : s38 ~ s53 google schola Giavarotti L / 2002 / Liver necrosis induced by acute intraperitoneal ethanol administration in aged rats / Free Radic Res 36 : 269 ~ 275 google schola Jang KT / 2001 / Effect of pehtoxifylline on liver fibrosis and cell cycle related proteins in thioacetamide -induced rat cirrhosis / Korean J Hepatol 7 : 281 ~ 291 google schola Jenkins SA / 1985 / A dimethylnitrosamine- induced model of cirrhosis and portal hypertension in the rat / Jouranal of Hepatology 1 : 489 ~ 499 google schola

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