지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives : The aim of this study was to evaluate the effects of Loranthus parasiticus Merr. on cell cycle and expression of related genes in HepG2 cells.
Methods : The MTT assay, cell counting assay, [3H]-Thymidine incorporation assay, flow cytometric analysis, quantitative RT-PCR and western blot assay were studied.
Results : In the water extract of Loranthus parasiticus Merr., inhibition of cell proliferation and DNA synthesis in HepG2 cells was seen. These inhibitory effects were due to inhibition of G1-S transition in cell cycle. After treatment with the extract, expression of cyclin D1(G1 check point related gene) was inhibited particularly in dose-dependent and time-dependent manners.
Conclusion : These results suggest that the inhibition of cell cycle progression by Loranthus parasiticus Merr. in HepG2 cell is due to suppression of cyclin D1(G1 check point related gene) mRNA expression and protein synthesis.
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참고문헌 (32)
참고문헌 신청
/ 1976 / The clonal evolution of tumor cell populations 194 : 23 ~ 8
/ 1991 / Amplification at chromosome 11q13 in transitional cell tumors of the bladder 6 : 789 ~ 95
/ 1992 / Amplication of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer 52 (19) : 5229 ~ 34
/ 1993 / Incidence and factors associated with intrahepatic recurrent following resection of hepatocellular carcinoma 105 (2) : 488 ~ 94
/ 1993 / The multistep nature of cancer : 138 ~ 41
/ 1991 / Amplification at chromosome 11q13 in transitional cell tumors of the bladder 6 : 789 ~ 95
/ 1992 / Amplication of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer 52 (19) : 5229 ~ 34
/ 1993 / Incidence and factors associated with intrahepatic recurrent following resection of hepatocellular carcinoma 105 (2) : 488 ~ 94
/ 1993 / The multistep nature of cancer : 138 ~ 41
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