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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한한방내과학회 대한한방내과학회지 대한한방내과학회지 제31권 제1호
발행연도
2010.1
수록면
128 - 141 (14page)

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Purpose : The object of this study was to observe the suppressive effects of Yijintang-gamibang (YJGMB), Yijintang with Atractylodis Rhizoma, Massa Medicata Fermentata, Hordei Fructus Germiniatus, and Coptidis Rhizoma. YJGMB has been traditionally used in Korean medicine for treating various digestive diseases. We tested it on the rat reflux esophagitis (RE) induced by pylorus and forestomach ligation in rats as compared with omeprazole, a well-known proton pump inhibitor. Method : Three different dosages of YJGMB 200, 100 and 50㎎/㎏, were orally pretreated once a day for 28 days before pylorus and forestomach ligation. Seven groups, each of 8 rats per group were used in the study. Six hours after pylorus and forestomach ligation, changes of the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, invasive lesion percentages, fundic mucosa and total thicknesses were measured as histomorphometry. The results were compared with omeprazole, antioxidant and proton pump inhibitor, and 30 and 10㎎/㎏ treated groups in which the effects on RE were already confirmed. Results : As results of pylorus and forestomach ligation, marked increases of esophageal and gastric mucosa lesion areas, gastric volumes, acid outputs, pepsin outputs were observed with histopathological changes of RE, such as hemorrhages, ulcerative lesions and edematous changes on the fundic mucosa. However, these pylorus and forestomach ligation-induced RE were dose-dependently inhibited by treatment of 200, 100 and 50㎎/㎏ of YJGMB. YJGMB 200㎎/㎏ showed similar protective effects as compared with 30㎎/㎏ of omeprazole in the present study, and more favorable effects were observed in 50㎎/㎏ of YJGMB treated rats as compared with omeprazole 10㎎/㎏ in the present study. Conclusion : The results obtained in this study suggest that YJGMB has favorable protective effects on the RE induced by pylorus and forestomach ligation. Therefore, it is expected that YJGMB will also show favorable effects on RE corresponding well to the suggestion of traditional Korean medicine. However, more detailed mechanism studies should be conducted in future with the screening of the biological active chemical compounds in herbs.
#Yijintang-gamibang #Reflux Esophagitis #Omeprazole

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참고문헌 (29)

참고문헌 신청
/ 1985 / Department of Health, Education, and Welfare Publication (National Institute of Health) : 85 ~ 123 google schola Bicakci U / 2005 / Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/ reoxygenation induced intestinal injury in newbo google schola DeVault KR / 1994 / Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease / Am J Gastroenterol : 1434 ~ 1440 google schola Dent J / 1994 / Omeprazole vs ranitidine for prevention of relapse in reflux oesophagitis / A controlled double blind trial of their efficacy and safety. Gut. 35 : 590 ~ 598 google schola Duarte CG / 2000 / The effect of the antithyroid drug propylthiouracil on the alternative pathway of complement in rats / Int J Immunopharmacol 22 : 25 ~ 33 google schola

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