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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 195 - 207 (13page)
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Objectives : The purpose of this study was to investigate how Rhei Radix et Rhizoma affects on insulin resistance and adipose tissue inflammatory response in high fat diet induced obese C57BL/6 mice.
Methods : Obesity was induced in C57BL/6 mice by high fat diet for 12 weeks. Models were divided into 3 groups (n=6) of normal diet, high fat diet (HFD), and high fat diet with Rhei Radix et Rhizoma and investigated for 12 weeks. We measured body weight, FBS and oral glucose tolerance test (OGTT), serum insulin, homeostatic model assessment-insulin resistance (HOMA-IR), weight of liver and epididymal fat pad. Inflammatory markers such as adipose tissue macrophage (ATM), tumor necrosis factor-α and interlukin-10 and CD68 of epididymal adipocyte were determined to evaluate the effect of Rhei Radix et Rhizoma on adipose tissue inflammation.
Results : Compared with the HFD group, we observed loss of body weight and epididymal fat pad weight, improvement of glucose level and HOMA-IR, reduction of ATM and gene expression of TNF-α, CD68 in the high fat diet with Rhei Radix et Rhizoma group.
Conclusions : This study suggests that Rhei Radix et Rhizoma has effects on insulin resistance and adipose tissue inflammatory response in high fat diet induced obese mice.
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참고문헌 (36)
참고문헌 신청
Arita Y / 1999 / Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity / Biochemical and Biophysical Research Communications 257 : 79 ~ 83
Bjorntorp P / 1996 / The regulation of adipose tissue distribution in humans / International Journal of Obesity and Related Metabolic Disorders 20 (4) : 291 ~ 302
Bonora E / 2000 / Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity / Diabetes Care 23 : 57 ~ 63
Flier JS / 1995 / The adipocyte: storage depot or node on the energy information superhighway / Cell 80 : 15 ~ 18
Maeda N / 2002 /
Bjorntorp P / 1996 / The regulation of adipose tissue distribution in humans / International Journal of Obesity and Related Metabolic Disorders 20 (4) : 291 ~ 302
Bonora E / 2000 / Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity / Diabetes Care 23 : 57 ~ 63
Flier JS / 1995 / The adipocyte: storage depot or node on the energy information superhighway / Cell 80 : 15 ~ 18
Maeda N / 2002 /
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