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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 891 - 901 (11page)
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초록· 키워드
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Objectives: The aim of the study was to evaluate the anti-asthmatic effect of alismatis rhizoma and alisol acetate B combination therapy in a murine asthma model.
Methods: C57BL/6 mice were sensitized to and challenged with a mixture of ragweed, dust mite, and aspergillus to induce an asthma animal model. Alismatis rhizoma extract and alisol acetate B combination therapy was co-administered only in the experimental group. To evaluate the anti-asthmatic effect of the combination therapy, inflammatory cell counts in bronchoalveolar lavage (BAL) fluid were determined, and tissue was examined histologically with hematoxylin and eosin (H & E) and periodic acid-Schiff (PAS) stains, by enzyme-linked immunosorbent assay (ELISA) of IgE, IL-4, and IL-5, and with reverse transcription polymerase chain reaction (RT-PCR) of IL-5, IL-33, MUC5AC.
Results: Alismatis rhizoma and alisol acetate B combination therapy reduced the number of inflammatory cells, alleviated histologic features, and down-regulated all the investigated asthma mediators, IgE, IL-4, IL-5, IL-33, and MUC5AC.
Conclusions: According to the above results, alismatis rhizoma and alisol acetate B combination therapy may have therapeutic potential for asthma.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Fuchs B / 2008 / Improved mouse models of allergy and allergic asthma-chances beyond ovalbumin / Curr Drug Targets 9(6):495~502
Goplen N / 2009 / Combined sensitization of mice to extracts of dust mite, ragweed, and Aspergillus species breaks through tolerance and establishes chronic features of asthma / J Allergy Clin Immunol 123(4):925~932
Van Hove CL / 2007 / Prolonged inhaled allergen exposure can induce persistent tolerance / Am J Respir Cell Mol Biol 36(5):573~584
Nemeth K / 2010 / Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed -induced asthma / Proc Natl Acad Sci USA 107(12):5652~5657
Wan YY / 2014 / GATA3: a master of many trades in immune regulation / Trends Immunol 35(6):233~242
Goplen N / 2009 / Combined sensitization of mice to extracts of dust mite, ragweed, and Aspergillus species breaks through tolerance and establishes chronic features of asthma / J Allergy Clin Immunol 123(4):925~932
Van Hove CL / 2007 / Prolonged inhaled allergen exposure can induce persistent tolerance / Am J Respir Cell Mol Biol 36(5):573~584
Nemeth K / 2010 / Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed -induced asthma / Proc Natl Acad Sci USA 107(12):5652~5657
Wan YY / 2014 / GATA3: a master of many trades in immune regulation / Trends Immunol 35(6):233~242
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