지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 83 - 101 (19page)
이용수
초록· 키워드
오류제보하기
Objectives : This study was aimed to investigate the therapeutic effect of Bogijetongtanggammi-bang (BJTG) on injury of the peripheral nerve tissues.
Methods : Rats were divided into 2 groups. The rats of the first group were injected with Taxol (1.25 mg/kg) to their sciatic nerves, once each. The sciatic nerves of the rats of the second group were crushed by forcept for 30 seconds. Rats were administered with BJTG (400 mg/kg) or 0.9% saline for 5 days. Changes of DRG neurons, Schwann cells, Cdc2, caspase 3. phospho-p44/42 Erk1/2, phospho-vimentin and β1 integrin were observed by fluorescent microscope and analysed in western blot.
Results : In Taxol-treated SD rat models, BJTG up-regulated neurite outgrowth, Schwann cells, Cdc2 and phospho-Erk1/2, and down-regulated caspase 3. In pressure-injured rat models, BJTG up-regulated axons of sciatic nerve, Schwann cells, Cdc2, phospho-vimentin, β1 integrin, and down-regulated caspase 3.
Conclusions : Taken together, BJTG was promotive of nerve regeneration on SNI as well as Taxol-induced nerve injury. BJTG had a pharmaceutical property enhancing recovery of injured peripheral nerves and could be a candidate for drug development after further research.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
[단행본]
Banker G / 1998 / Culturing nerve cells / MIT press : 1 ~ 678
Dougherty PM / 2004 / Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients / Pain 109 : 132 ~ 142
Fidanboylu M / 2011 / Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy / PLoS One 6 (9) : 25212 ~
Flatters SJ / 2006 / Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction / Pain 122 : 245 ~ 257
Banker G / 1998 / Culturing nerve cells / MIT press : 1 ~ 678
Dougherty PM / 2004 / Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients / Pain 109 : 132 ~ 142
Fidanboylu M / 2011 / Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy / PLoS One 6 (9) : 25212 ~
Flatters SJ / 2006 / Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction / Pain 122 : 245 ~ 257
이 논문의 저자 정보
최근 본 자료
댓글(0)
0